Developmental Pattern of Perineuronal Nets in the Human Prefrontal Cortex and Their Deficit in Schizophrenia

• Published in: Biological psychiatry (1969) Vol. 74; no. 6; pp. 427 - 435
• Main Authors: Mauney, Sarah A., Athanas, Katina M., Pantazopoulos, Harry, Shaskan, Noel, Passeri, Eleonora, Berretta, Sabina, Woo, Tsung-Ung W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.09.2013
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Bipolar disorder; Bipolar Disorder - pathology; cerebral cortex; Child; Child, Preschool; development; Extracellular Matrix - pathology; Female; GABA; Humans; Infant; Infant, Newborn; Male; Middle Aged; Nerve Net - growth & development; Nerve Net - pathology; Prefrontal Cortex - growth & development; Prefrontal Cortex - pathology; Psychiatric/Mental Health; schizophrenia; Schizophrenia - pathology; synaptic pruning; Young Adult; GABA; cerebral cortex; Bipolar disorder; development; schizophrenia; synaptic pruning

Perineuronal nets (PNNs) are extracellular matrix structures that enwrap many neurons in the brain. They regulate the postnatal experience-dependent maturation of brain circuits and maintain their functional integrity in the mature brain by stabilizing their synaptic architecture. Eighty-six postmor...