Renal renin-angiotensin system activity in naturally reared and cross-fostered spontaneously hypertensive rats

• Published in: American journal of hypertension Vol. 16; no. 10; pp. 864 - 869
• Main Authors: Gouldsborough, Ingrid, Lindop, George B.M, Ashton, Nick
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2003; Oxford University Press; Elsevier Science
• Subjects: Angiotensin II - blood; Angiotensin II - pharmacology; Animals; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; cross-fostering; Cyclic AMP - metabolism; Experimental diseases; Female; Gene Expression; Hypertension, Renal - metabolism; In Situ Hybridization; Kidney; Kidney Tubules, Proximal - drug effects; Kidney Tubules, Proximal - metabolism; Medical sciences; Pregnancy; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1 - genetics; Renin - genetics; renin-angiotensin system; Renin-Angiotensin System - physiology; Second Messenger Systems - physiology; Social Environment; Species Specificity; spontaneously hypertensive rat; Vasoconstrictor Agents - blood; Vasoconstrictor Agents - pharmacology; spontaneously hypertensive rat; cross-fostering; Kidney; renin-angiotensin system; Hypertension; Rat; Pathogenesis; Rodentia; Cardiovascular disease; Hereditary; Vertebrata; Renin angiotensin system; Mammalia; Animal

Young (4 week) spontaneously hypertensive rats (SHR) exhibit greater renal responses to angiotensin II (Ang II) than normotensive Wistar Kyoto (WKY) rats. SHR pups cross-fostering to a WKY dam at birth (SHRX) are less sensitive to Ang II and have lower adult blood pressure. The aim of this study was...