Mechanisms of FSH synthesis: what we know, what we don't, and why you should care

• Published in: Fertility and sterility Vol. 93; no. 8; pp. 2465 - 2485
• Main Authors: Bernard, Daniel J., Fortin, Jérôme, Wang, Ying, Lamba, Pankaj
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.05.2010; Elsevier
• Subjects: Activins - physiology; Androgens - physiology; Animals; Base Sequence; Biological and medical sciences; Cell Line; Estrogens - physiology; Female; Follicle Stimulating Hormone, beta Subunit - biosynthesis; Follicle Stimulating Hormone, beta Subunit - secretion; Follistatin - physiology; GATA2 Transcription Factor - physiology; Gene Expression Regulation; Glycoprotein Hormones, alpha Subunit; Gonadotrophs - metabolism; Gonadotropin-Releasing Hormone - physiology; Gynecology. Andrology. Obstetrics; Homeodomain Proteins - genetics; Homeodomain Proteins - physiology; Humans; Inhibins - physiology; Internal Medicine; LIM-Homeodomain Proteins; Male; Medical sciences; Molecular Sequence Data; Obstetrics and Gynecology; Paired Box Transcription Factors - physiology; Promoter Regions, Genetic - physiology; Sequence Alignment; Species Specificity; Steroidogenic Factor 1 - physiology; Transcription Factors; Synthesis; Obstetrics; Gynecology; Follicle stimulating hormone

The pituitary gonadotropin hormones, FSH and LH, are key regulators of reproductive physiology. Though the two hormones are produced by the same cell type, often in response to the same endocrine and paracrine regulators, they sub-serve different biological functions and their synthesis and secretio...