Prediction of Cardiac Death in Hemodialysis Patients by Myocardial Fatty Acid Imaging

• Published in: Journal of the American College of Cardiology Vol. 51; no. 2; pp. 139 - 145
• Main Authors: Nishimura, Masato, MD, PhD, Tsukamoto, Kazumasa, PhD, Hasebe, Naoyuki, MD, PhD, Tamaki, Nagara, MD, PhD, Kikuchi, Kenjiro, MD, PhD, Ono, Toshihiko, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.01.2008; Elsevier Limited
• Subjects: Aged; Aged, 80 and over; Cardiology; Cardiovascular; Cardiovascular disease; Cohort Studies; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - etiology; Coronary Artery Disease - mortality; Death; Death, Sudden, Cardiac; Fatty Acids; Female; Heart attacks; Hemodialysis; Humans; Internal Medicine; Kidney Failure, Chronic - diagnosis; Kidney Failure, Chronic - therapy; Male; Medical imaging; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Probability; Proportional Hazards Models; Prospective Studies; Renal Dialysis - adverse effects; Renal Dialysis - methods; Risk Assessment; ROC Curve; Sensitivity and Specificity; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Japan; CHF; CRP; ESRD; 123I; C-reactive protein; myocardial infarction; LV; SPECT; thallium; receiver-operating characteristic; BMIPP; Tl; congestive heart failure; left ventricular; MI; ROC; percutaneous coronary artery intervention; coronary artery bypass graft; end-stage renal disease; β-methyl iodophenyl-pentadecanoic acid; adenosine triphosphate; PCI; CABG; ATP; 123iodine; single-photon emission computed tomography
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.08.057

Prediction of Cardiac Death in Hemodialysis Patients by Myocardial Fatty Acid Imaging Masato Nishimura, Kazumasa Tsukamoto, Naoyuki Hasebe, Nagara Tamaki, Kenjiro Kikuchi, Toshihiko Ono This prospective cohort study showed that the occurrence of cardiac death among patients on maintenance hemodialysis is closely associated with severely abnormal β-methyl iodophenyl-pentadecanoic acid (BMIPP) single-photon emission computed tomography images. Kaplan-Meier survival estimates showed that survival rates worsened with an increasing summed BMIPP score. Highly impaired myocardial fatty acid metabolism can identify groups of hemodialysis patients at high risk for cardiac death.