Transcriptional Alterations in Dorsolateral Prefrontal Cortex and Nucleus Accumbens Implicate Neuroinflammation and Synaptic Remodeling in Opioid Use Disorder

• Published in: Biological psychiatry (1969) Vol. 90; no. 8; pp. 550 - 562
• Main Authors: Seney, Marianne L., Kim, Sam-Moon, Glausier, Jill R., Hildebrand, Mariah A., Xue, Xiangning, Zong, Wei, Wang, Jiebiao, Shelton, Micah A., Phan, BaDoi N., Srinivasan, Chaitanya, Pfenning, Andreas R., Tseng, George C., Lewis, David A., Freyberg, Zachary, Logan, Ryan W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.10.2021
• Subjects: Analgesics, Opioid - therapeutic use; Genome-Wide Association Study; Human postmortem brain; Humans; Neuroinflammation; Nucleus Accumbens; Opioid use disorder; Opioid-Related Disorders - genetics; Prefrontal Cortex; Psychiatric/Mental Health; RNA-seq; Neuroinflammation; RNA-seq; Opioid use disorder; Human postmortem brain

Prevalence rates of opioid use disorder (OUD) have increased dramatically, accompanied by a surge of overdose deaths. While opioid dependence has been extensively studied in preclinical models, an understanding of the biological alterations that occur in the brains of people who chronically use opio...