Differentiating the Effect of an Opioid Agonist on Cardiac Repolarization From µ-Receptor–mediated, Indirect Effects on the QT Interval: A Randomized, 3-way Crossover Study in Healthy Subjects - Darpo, Borje; Zhou, Meijian; Bai, Stephen A.; Ferber, Georg; Xiang, Qinfang; Finn, Andrew (CLINICAL THERAPEUTICS, 2016)
Keywords: Adult; buprenorphine; Buprenorphine - pharmacology; Cardiac arrhythmia; Cross-Over Studies; Double-Blind Method; Drug dosages; Electrocardiography; Electrocardiography - drug effects; Female; Fluoroquinolones - pharmacology; Fridericia; Heart - drug effects; Heart Rate - drug effects; Humans; Internal Medicine; Laboratories; Long QT syndrome; Male; Medical Education; naltrexone; Naltrexone - pharmacology; opioids; Pain; Pharmaceuticals; Plasma; QT prolongation; Stock options; Substance abuse treatment; thorough QT study; µ-receptor blockade; United States--US; µ-receptor blockade; naltrexone; buprenorphine; QT prolongation; thorough QT study; opioids