Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology

• Published in: Cancer research (Chicago, Ill.) Vol. 76; no. 2; pp. 418 - 428
• Main Authors: Dutta, Samikshan, Roy, Sohini, Polavaram, Navatha S, Stanton, Marissa J, Zhang, Heyu, Bhola, Tanvi, Hönscheid, Pia, Donohue, Jr, Terrence M, Band, Hamid, Batra, Surinder K, Muders, Michael H, Datta, Kaustubh
• Format: Journal Article
• Language: English
• Published: United States 15.01.2016
• Subjects: Cell Line, Tumor; Endosomes - metabolism; ErbB Receptors - metabolism; Humans; Neoplasms - genetics; Neoplasms - pathology; Neuropilin-2 - genetics; Neuropilin-2 - metabolism

Neuropilin-2 (NRP2) is a non-tyrosine kinase receptor frequently overexpressed in various malignancies, where it has been implicated in promoting many protumorigenic behaviors, such as imparting therapeutic resistance to metastatic cancer cells. Here, we report a novel function of NRP2 as a regulato...