Frequent Detection of Pancreatic Lesions in Asymptomatic High-Risk Individuals

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 142; no. 4; pp. 796 - 804
• Main Authors: Canto, Marcia Irene, Hruban, Ralph H., Fishman, Elliot K., Kamel, Ihab R., Schulick, Richard, Zhang, Zhe, Topazian, Mark, Takahashi, Naoki, Fletcher, Joel, Petersen, Gloria, Klein, Alison P., Axilbund, Jennifer, Griffin, Constance, Syngal, Sapna, Saltzman, John R., Mortele, Koenraad J., Lee, Jeffrey, Tamm, Eric, Vikram, Raghunandan, Bhosale, Priya, Margolis, Daniel, Farrell, James, Goggins, Michael
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2012
• Subjects: Academic Medical Centers; Aged; Asymptomatic Diseases; Chi-Square Distribution; Diagnostic Imaging - methods; Endosonography; Familial Pancreatic Cancer; Female; Gastroenterology and Hepatology; Genetic Predisposition to Disease; Heredity; Humans; IPMN; Logistic Models; Magnetic Resonance Imaging; Male; Middle Aged; Multivariate Analysis; Pancreatic Cyst - diagnosis; Pancreatic Cyst - epidemiology; Pancreatic Cyst - genetics; Pancreatic Cyst - pathology; Pancreatic Cyst - surgery; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - epidemiology; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - surgery; PanIN; Pedigree; Predictive Value of Tests; Prevalence; Prognosis; Prospective Studies; Risk Assessment; Risk Factors; Surveillance; Tomography, X-Ray Computed; United States - epidemiology; United States; BD; EUS; MRI; IPMN; FAMMM; CT; PC; Surveillance; MRCP; PanIN; FPC; PJS; Familial Pancreatic Cancer; CAPS; HRI; high-risk individuals; magnetic resonance imaging; pancreatic cancer; endoscopic ultrasonography; computed tomography; branch duct; intraductal papillary mucinous neoplasm; American Cancer of the Pancreas Screening Consortium; Peutz–Jeghers syndrome; familial atypical multiple mole melanoma; pancreatic intraepithelial neoplasia; magnetic resonance cholangiopancreatography

The risk of pancreatic cancer is increased in patients with a strong family history of pancreatic cancer or a predisposing germline mutation. Screening can detect curable, noninvasive pancreatic neoplasms, but the optimal imaging approach is not known. We determined the baseline prevalence and chara...