Pica as an adaptive response: Kaolin consumption helps rats recover from chemotherapy-induced illness
Abstract Clay consumption can occur during illness but there has been little work to understand why. To investigate whether consuming clay confers an advantage to the sick animal, we compared the recovery from illness of adult male rats with or without access to kaolin. Illness was induced by inject...
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Published in | Physiology & behavior Vol. 97; no. 1; pp. 87 - 90 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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20.04.2009
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Abstract | Abstract Clay consumption can occur during illness but there has been little work to understand why. To investigate whether consuming clay confers an advantage to the sick animal, we compared the recovery from illness of adult male rats with or without access to kaolin. Illness was induced by injection of 6 mg/kg, ip, cisplatin, a toxic chemotherapy agent, and recovery was assessed by changes in daily food intake, water intake, and body weight. Relative to saline-injected controls, cisplatin-injected rats reduced food and water intake and lost weight. However, those with access to kaolin ate more food and lost less body weight than did those without access to kaolin. Thus, clay consumption appeared beneficial in that it either protected the rats from illness or enhanced recovery and might prove useful as an adjunct therapy for other animals, including humans, experiencing visceral malaise. |
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AbstractList | Clay consumption can occur during illness but there has been little work to understand why. To investigate whether consuming clay confers an advantage to the sick animal, we compared the recovery from illness of adult male rats with or without access to kaolin. Illness was induced by injection of 6 mg/kg, ip, cisplatin, a toxic chemotherapy agent, and recovery was assessed by changes in daily food intake, water intake, and body weight. Relative to saline-injected controls, cisplatin-injected rats reduced food and water intake and lost weight. However, those with access to kaolin ate more food and lost less body weight than did those without access to kaolin. Thus, clay consumption appeared beneficial in that it either protected the rats from illness or enhanced recovery and might prove useful as an adjunct therapy for other animals, including humans, experiencing visceral malaise. Clay consumption can occur during illness but there has been little work to understand why. To investigate whether consuming clay confers an advantage to the sick animal, we compared the recovery from illness of adult male rats with or without access to kaolin. Illness was induced by injection of 6 mg/kg, ip, cisplatin, a toxic chemotherapy agent, and recovery was assessed by changes in daily food intake, water intake, and body weight. Relative to saline-injected controls, cisplatin-injected rats reduced food and water intake and lost weight. However, those with access to kaolin ate more food and lost less body weight than did those without access to kaolin. Thus, clay consumption appeared beneficial in that it either protected the rats from illness or enhanced recovery and might prove useful as an adjunct therapy for other animals, including humans, experiencing visceral malaise. Abstract Clay consumption can occur during illness but there has been little work to understand why. To investigate whether consuming clay confers an advantage to the sick animal, we compared the recovery from illness of adult male rats with or without access to kaolin. Illness was induced by injection of 6 mg/kg, ip, cisplatin, a toxic chemotherapy agent, and recovery was assessed by changes in daily food intake, water intake, and body weight. Relative to saline-injected controls, cisplatin-injected rats reduced food and water intake and lost weight. However, those with access to kaolin ate more food and lost less body weight than did those without access to kaolin. Thus, clay consumption appeared beneficial in that it either protected the rats from illness or enhanced recovery and might prove useful as an adjunct therapy for other animals, including humans, experiencing visceral malaise. |
Author | De Jonghe, Bart C Tordoff, Michael G Horn, Charles C Lawler, Maureen P |
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Keywords | Clay Pica Nausea Vagus Emesis Cisplatin Antineoplastic agent Rat Rodentia Adaptive response Pharmacotherapy Eating disorder Alkylating agent Vertebrata Chemotherapy Mammalia Treatment Animal Platinum II Complexes |
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Snippet | Abstract Clay consumption can occur during illness but there has been little work to understand why. To investigate whether consuming clay confers an advantage... Clay consumption can occur during illness but there has been little work to understand why. To investigate whether consuming clay confers an advantage to the... |
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SubjectTerms | Animals Behavioral psychophysiology Biological and medical sciences Body Weight - drug effects Cisplatin Cisplatin - poisoning Clay Drinking - drug effects Drug Interactions Eating - drug effects Emesis Fundamental and applied biological sciences. Psychology Kaolin - pharmacology Male Nausea Pica Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Vagus |
Title | Pica as an adaptive response: Kaolin consumption helps rats recover from chemotherapy-induced illness |
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