Acute effect of hydrocortisone for respiratory deterioration in preterm infants: Oxygenation, ventilation, vital signs, and electrolytes

• Published in: Early Human Development Vol. 154; p. 105320
• Main Authors: Shimokaze, Tomoyuki, Toyoshima, Katsuaki, Noguchi, Takahiro, Aoki, Hirosato, Saito, Tomoko
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.03.2021; Elsevier BV
• Subjects: Adrenal insufficiency; Advanced Basic Science; Bradycardia; Bronchopulmonary Dysplasia; Dexamethasone; Electrolytes; Humans; Hydrocortisone; Hypertension; Infant; Infant, Newborn; Infant, Premature; Neonatal and Perinatal Medicine; Oxygen Saturation; Retrospective Studies; SpO2/FiO2 ratio; Vital Signs; Hypertension; Bradycardia; Adrenal insufficiency; Dexamethasone; SpO2/FiO2 ratio; pCO2; BPD; SpO2; FiO2; Bronchopulmonary dysplasia; SpO 2; SpO 2/FiO 2 ratio; peripheral capillary oxygen saturation; pCO 2; partial pressure of carbon dioxide; bronchopulmonary dysplasia; FiO 2; fraction of inspired oxygen; SpO/FiO ratio

Preterm infants with severe bronchopulmonary dysplasia require rescue therapy with glucocorticoids, and hydrocortisone is increasingly replacing dexamethasone. The standard for rescue therapy is unclear. To quantify the short-term effects of respiratory rescue hydrocortisone of 4 mg/kg/day for 3 day...