Aspects of matrix effects in applications of liquid chromatography–mass spectrometry to forensic and clinical toxicology—a review

• Published in: Analytical and bioanalytical chemistry Vol. 403; no. 8; pp. 2155 - 2172
• Main Authors: Peters, Frank T., Remane, Daniela
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.06.2012; Springer
• Subjects: Analysis; Analytical Chemistry; Animals; Biochemistry; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Chromatography, Liquid - methods; Food Science; Forensic engineering; Forensic Medicine - methods; Forensic toxicology; Forensic Toxicology - methods; Humans; Ionization; Ions - chemistry; Laboratory Medicine; Liquid chromatography; Liquids; Mass spectrometry; Mass Spectrometry - methods; Mathematical analysis; Matrices; Monitoring/Environmental Analysis; Review; Technology application; Toxicity; Toxicology; Germany; Ion enhancement; Liquid chromatography; Matrix effect; Ion suppression; Mass spectrometry

In the last decade, liquid chromatography coupled to (tandem) mass spectrometry (LC–MS(−MS)) has become a versatile technique with many routine applications in clinical and forensic toxicology. However, it is well-known that ionization in LC–MS(−MS) is prone to so-called matrix effects, i.e., altera...