A Standardized [18F]-FDG-PET Template for Spatial Normalization in Statistical Parametric Mapping of Dementia

• Published in: Neuroinformatics (Totowa, N.J.) Vol. 12; no. 4; pp. 575 - 593
• Main Authors: Della Rosa, Pasquale Anthony, Cerami, Chiara, Gallivanone, Francesca, Prestia, Annapaola, Caroli, Anna, Castiglioni, Isabella, Gilardi, Maria Carla, Frisoni, Giovanni, Friston, Karl, Ashburner, John, Perani, Daniela
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.10.2014; Springer; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Applied sciences; Artificial intelligence; Bioinformatics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Brain - diagnostic imaging; Brain Mapping - methods; Case-Control Studies; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - physiopathology; Cognitive Dysfunction - psychology; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Computer science; control theory; systems; Dementia; Dementia - diagnostic imaging; Dementia - physiopathology; Dementia - psychology; Exact sciences and technology; Female; Fluorodeoxyglucose F18; Geriatrics; Humans; Image Processing, Computer-Assisted - methods; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Neurology; Neurosciences; Original Article; Pattern recognition. Digital image processing. Computational geometry; Positron-Emission Tomography - methods; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Sensitivity and Specificity; F-FDG PET; Spatial normalization; SPM (RRID:nif-0000-00343); Template; Dementia; F-FDGPET; Brain; 2-deoxy-2-fluoroglucose; Statistical analysis; Probabilistic approach; Pathophysiology; Alzheimer disease; Ageing; Normal form; Central nervous system; Glucose; Scintigraphy; Metabolism; Statistical method; Positron computed tomography; Morphology; Voxel; Tridimensional image; Diagnosis; Positron emission tomography

[ 18 F]-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) is a widely used diagnostic tool that can detect and quantify pathophysiology, as assessed through changes in cerebral glucose metabolism. [ 18 F]-FDG PET scans can be analyzed using voxel-based statistical methods such as Statistic...