Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism

• Published in: Cell Vol. 177; no. 5; pp. 1124 - 1135.e16
• Main Authors: Watanabe, Akiko, McCarthy, Kevin R., Kuraoka, Masayuki, Schmidt, Aaron G., Adachi, Yu, Onodera, Taishi, Tonouchi, Keisuke, Caradonna, Timothy M., Bajic, Goran, Song, Shengli, McGee, Charles E., Sempowski, Gregory D., Feng, Feng, Urick, Patricia, Kepler, Thomas B., Takahashi, Yoshimasa, Harrison, Stephen C., Kelsoe, Garnett
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.05.2019; Elsevier
• Subjects: Adult; Animals; antibodies; Antibodies, Viral - immunology; B-lymphocytes; BASIC BIOLOGICAL SCIENCES; Dogs; epitopes; Epitopes - immunology; Female; Hemagglutinin Glycoproteins, Influenza Virus - immunology; hemagglutinins; Humans; humoral immunity; immunoglobulin G; Immunoglobulin G - immunology; influenza; Influenza A virus - immunology; influenza vaccines; Influenza Vaccines - immunology; Madin Darby Canine Kidney Cells; Male; Mice; Middle Aged; Orthomyxoviridae; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - pathology; Orthomyxoviridae Infections - prevention & control; pathogens

Vaccines to generate durable humoral immunity against antigenically evolving pathogens such as the influenza virus must elicit antibodies that recognize conserved epitopes. Analysis of single memory B cells from immunized human donors has led us to characterize a previously unrecognized epitope of i...