Methylation Mediated Silencing of miR-155 Suppresses the Development of Preeclampsia In Vitro and In Vivo by Targeting FOXO3

• Published in: Mediators of inflammation Vol. 2022; pp. 1 - 20
• Main Authors: Luo, Xiaohua, Pan, Ci, Guo, Xiaopei, Gu, Cunhua, Huang, Yulian, Guo, Jing, Zeng, Ying, Yue, Jinjing, Cui, Shihong
• Format: Journal Article
• Language: English
• Published: United States Hindawi 26.05.2022; John Wiley & Sons, Inc; Wiley
• Subjects: Analysis; Animals; Apoptosis; Arginine; B cells; Cell adhesion & migration; Cell culture; Cell growth; Cell Line, Tumor; Cell Movement - genetics; Cell proliferation; Cell Proliferation - genetics; Cholecystokinin; Cytokines; DNA methylation; Enzyme-linked immunosorbent assay; Female; Forkhead Box Protein O3 - genetics; Forkhead Box Protein O3 - metabolism; FOXO3 protein; Gelatinase A; Gene expression; Humans; Immune response; Inflammation; Inflammation - metabolism; Methylation; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; NG-Nitroarginine methyl ester; Oxidative stress; Pathogenesis; Peripheral blood; Placenta; Placenta - metabolism; Pre-eclampsia; Pre-Eclampsia - metabolism; Preeclampsia; Pregnancy; Rats; Reverse transcription; Transfection; Trophoblasts - metabolism; Womens health; Canada; China; United States > US

Preeclampsia (PE) is a common pregnancy-related syndrome characterized by chronic immune activation. This study is aimed at exploring the role of miR-155 in the inflammatory pathogenesis of PE. Placental tissues and peripheral blood were collected from all subjects. BSP detection analysis was perfor...