Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene

• Published in: The international journal of neuropsychopharmacology Vol. 18; no. 2; p. pyu032
• Main Authors: Wei, Ya Bin, Melas, Philippe A., Wegener, Gregers, Mathé, Aleksander A., Lavebratt, Catharina
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2015
• Subjects: Animals; Antidepressants; Antidepressive Agents - pharmacology; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Butyric Acid - pharmacology; Depressive Disorder - drug therapy; Depressive Disorder - genetics; Depressive Disorder - metabolism; Dioxygenases - metabolism; Disease Models, Animal; DNA methylation; DNA Methylation - drug effects; Epigenetics; Histone Deacetylase Inhibitors - pharmacology; Male; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Rats; Up-Regulation - drug effects; DNA methylation; TET1; depression; epigenetics

Background:Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant effects remain unknown. While research using NaB has mainly focused on its role as a histone deacetylase inhibitor (HDACi), there i...