Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice

• Published in: Aging cell Vol. 19; no. 1; pp. e13059 - n/a
• Main Authors: Tian, Qiyu, Zhao, Junxing, Yang, Qiyuan, Wang, Bo, Deavila, Jeanene M., Zhu, Mei-Jun, Du, Min
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.01.2020; John Wiley and Sons Inc
• Subjects: Adipocytes; Adipogenesis; Adipogenesis - drug effects; Adipose tissue (brown); adipose tissue browning; Adipose tissues; Aging; alpha‐ketoglutarate; Animals; Body fat; Body weight; Body weight gain; Demethylation; Deoxyribonucleic acid; Dextrose; Diabetes mellitus; Dietary supplements; DNA; DNA demethylation; DNA methylation; Fatty acids; Female; Genes; Glucose; Glucose tolerance; High fat diet; Hypertrophy; Ketoglutaric acid; Ketoglutaric Acids - pharmacology; Ketoglutaric Acids - therapeutic use; Metabolic disorders; Metabolism; Methylation; Mice; Obesity; Obesity - drug therapy; Obesity - prevention & control; Original; Proteins; DNA demethylation; aging; glucose tolerance; alpha-ketoglutarate; adipose tissue browning; high-fat diet

Aging usually involves the progressive development of certain illnesses, including diabetes and obesity. Due to incapacity to form new white adipocytes, adipose expansion in aged mice primarily depends on adipocyte hypertrophy, which induces metabolic dysfunction. On the other hand, brown adipose ti...