Model‐informed target identification and validation through combining quantitative systems pharmacology with network‐based analysis

• Published in: CPT: pharmacometrics and systems pharmacology Vol. 11; no. 4; pp. 399 - 402
• Main Authors: Chelliah, Vijayalakshmi, van der Graaf, Piet H.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.04.2022; John Wiley and Sons Inc; Wiley
• Subjects: Biology; Biomarkers; Cancer; Clinical trials; Datasets; Drugs; Efficiency; Humans; Hypotheses; Identification; Network Pharmacology; Patients; Pharmacology; Proteins; R&D; Research & development; Success

[...]in silico screening of an entire molecular network in the context of the whole genome may be more effective in identifying potential targets that simultaneously modulate multiple disease genes. [...]it facilitates exploring “multiple drugs, multiple targets, multiple pathways operating in multi...