Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma

• Published in: Cancer communications (London, England) Vol. 42; no. 4; pp. 287 - 313
• Main Authors: Zhang, Xiao, Xu, Yunhua, Ma, Lifang, Yu, Keke, Niu, Yongjie, Xu, Xin, Shi, Yi, Guo, Susu, Xue, Xiangfei, Wang, Yikun, Qiu, Shiyu, Cui, Jiangtao, Wang, Hong, Tian, Xiaoting, Miao, Yayou, Meng, Fanyu, Qiao, Yongxia, Yu, Yongchun, Wang, Jiayi
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.04.2022; John Wiley and Sons Inc; Wiley
• Subjects: Adenocarcinoma of Lung - genetics; Animals; Cancer; Cell adhesion & migration; circRNA_101093; desensitization; Desensitization (Psychology); Epidermal growth factor; exosome; Exosomes - genetics; Exosomes - metabolism; Exosomes - pathology; Fatty acids; FDA approval; Ferroptosis; Humans; lipid peroxidation; lung adenocarcinoma; Lung cancer; Lung Neoplasms - pathology; Lymphoma; Mass spectrometry; Metabolism; Metabolites; Mice; Mutation; N‐arachidonoyl taurine; Original; poly‐unsaturated fatty acid; Proteins; Proteomics; Reactive oxygen species; RNA, Circular - genetics; RNA‐protein interaction; Sarcoma; Scientific imaging; Taurine; Tumorigenesis; Variance analysis; United States > US; China; ferroptosis; lung adenocarcinoma; taurine; RNA-protein interaction; circRNA_101093; exosome; lipid peroxidation; poly-unsaturated fatty acid; desensitization; N-arachidonoyl taurine

Background Resistance to ferroptosis, a regulated cell death caused by iron‐dependent excessive accumulation of lipid peroxides, has recently been linked to lung adenocarcinoma (LUAD). Intracellular antioxidant systems are required for protection against ferroptosis. The purpose of the present study...