Genes adopt non‐optimal codon usage to generate cell cycle‐dependent oscillations in protein levels

• Published in: Molecular systems biology Vol. 8; no. 1; pp. 572 - n/a
• Main Authors: Frenkel‐Morgenstern, Milana, Danon, Tamar, Christian, Thomas, Igarashi, Takao, Cohen, Lydia, Hou, Ya‐Ming, Jensen, Lars Juhl
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.02.2012; John Wiley & Sons, Ltd; EMBO Press; Nature Publishing Group; Springer Nature
• Subjects: Arabidopsis; Base Sequence; Biological Clocks - genetics; Cell cycle; Cell Cycle - genetics; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Cycle Proteins - physiology; Cell division; Codon - genetics; Codons; Deoxyribonucleic acid; DNA; DNA biosynthesis; EMBO06; EMBO32; EMBO36; Ethanol; Experiments; G2 phase; Gene expression; Gene Expression Regulation - genetics; Genes; Genes - physiology; Genetic Code - physiology; Genomes; Humans; Mathematical models; Models, Biological; Models, Theoretical; non‐optimal codons; Oscillations; Phenols; Protein biosynthesis; Protein synthesis; Proteins; Proteins - genetics; Proteins - metabolism; Ribonucleic acid; RNA; Saccharomyces cerevisiae; Schizosaccharomyces; translation regulation; tRNA; tRNA expression during cell cycle; wobbling; Yeast; translation regulation; tRNA expression during cell cycle; wobbling; cell cycle; non‐optimal codons

The cell cycle is a temporal program that regulates DNA synthesis and cell division. When we compared the codon usage of cell cycle‐regulated genes with that of other genes, we discovered that there is a significant preference for non‐optimal codons. Moreover, genes encoding proteins that cycle at t...