Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

• Published in: Aging cell Vol. 17; no. 5; pp. e12802 - n/a
• Main Authors: Xia, Xian, Jiang, Quanlong, McDermott, Joseph, Han, Jing‐Dong J.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.10.2018; John Wiley and Sons Inc
• Subjects: Aging; Aging - pathology; Alzheimer Disease - genetics; Alzheimer Disease - microbiology; Alzheimer Disease - pathology; Alzheimer's disease; Amyloidosis; Analysis; cell type composition; comparison and association; Dementia disorders; DNA Methylation - genetics; epigenetics; genetic susceptibility; Humans; Hypotheses; Life Style; Microbiota; microglia; Neurodegenerative diseases; Review; Reviews; Risk factors; system inflammation; Systems Biology; Tau protein; comparison and association; Alzheimer’s disease; cell type composition; aging; genetic susceptibility; microglia; epigenetics; system inflammation

Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzh...