Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzh...

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Bibliographic Details
Published inAging cell Vol. 17; no. 5; pp. e12802 - n/a
Main Authors Xia, Xian, Jiang, Quanlong, McDermott, Joseph, Han, Jing‐Dong J.
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.10.2018
John Wiley and Sons Inc
Subjects
Aging
Aging - pathology
Alzheimer Disease - genetics
Alzheimer Disease - microbiology
Alzheimer Disease - pathology
Alzheimer's disease
Amyloidosis
Analysis
cell type composition
comparison and association
Dementia disorders
DNA Methylation - genetics
epigenetics
genetic susceptibility
Humans
Hypotheses
Life Style
Microbiota
microglia
Neurodegenerative diseases
Review
Reviews
Risk factors
system inflammation
Systems Biology
Tau protein
comparison and association
Alzheimer’s disease
cell type composition
aging
genetic susceptibility
microglia
epigenetics
system inflammation
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Summary:Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.
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These authors contributed equally to this work.
ISSN:1474-9718
1474-9726
1474-9726
DOI:10.1111/acel.12802