circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer

• Published in: Cancer communications (London, England) Vol. 43; no. 1; pp. 100 - 122
• Main Authors: Yang, Yufei, Luo, Dakui, Shao, Yang, Shan, Zezhi, Liu, Qi, Weng, Junyong, He, Weijing, Zhang, Ruoxin, Li, Qingguo, Wang, Ziliang, Li, Xinxiang
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2023; John Wiley and Sons Inc; Wiley
• Subjects: ACC1; Acetyl-CoA Carboxylase - genetics; Angiogenesis; Apoptosis; Biomarkers; Biosynthesis; Carcinogenesis; Cell growth; circCAPRIN1; circRNA; Colorectal cancer; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Cyclin-dependent kinases; Dehydrogenases; Disease; Fatty acids; Humans; In Situ Hybridization, Fluorescence; Kinases; lipid metabolism; Lipids; Lipids - biosynthesis; Medical prognosis; Metabolism; Metastasis; MicroRNAs; Neoplastic Processes; Original; Oxidation; Proteins; RNA, Circular - genetics; STAT2; STAT2 Transcription Factor - genetics; STAT2 Transcription Factor - metabolism; Transcription factors; colorectal cancer; circRNA; circCAPRIN1; STAT2; ACC1; lipid metabolism

Background Circular RNAs (circRNAs) generated by back‐splicing of precursor mRNAs (pre‐mRNAs) are often aberrantly expressed in cancer cells. Accumulating evidence has revealed that circRNAs play a critical role in the progression of several cancers, including colorectal cancer (CRC). However, the c...