Physiologically‐based pharmacokinetic modeling of remdesivir and its metabolites in pregnant women with COVID‐19 - Liu, Xiaomei I.; Dallmann, André; Brooks, Kristina; Best, Brookie M.; Clarke, Diana F.; Mirochnick, Mark; Anker, John N.; Capparelli, Edmund V.; Momper, Jeremiah D. (CPT: pharmacometrics and systems pharmacology, 2023)
Keywords: Adenosine; Adolescent; Adult; Antiviral drugs; Case Report; Child; Coronaviruses; COVID-19; COVID-19 Drug Treatment; Drug development; Drug dosages; Enzymes; Female; Gestational age; Humans; Metabolism; Metabolites; Models, Biological; Pharmacokinetics; Physiology; Plasma; Population; Pregnancy; Pregnant Women; Ratios; RNA polymerase; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2