脑梗死急性期梗死部位及白质病变与认知功能关系的临床分析

目的研究急性脑梗死患者梗死部位及是否合并脑白质病变对患者早期认知功能的影响. 方法采用临床痴呆评定量表、简易精神状态检查量表和中文版蒙特利尔认知评估量表对连续入组的急性脑梗死患者进行认知心理学评估,分析患者不同梗死部位包括皮层梗死、皮层下关键部位梗死和皮层下非关键部位梗死及是否合并白质病变对患者认知功能的影响. 结果急性脑梗死患者血管性认知功能障碍组的平均年龄显著高于无认知功能障碍组(67.3110.88 vs 57.099.91,P=0.015),神经功能缺损评分显著高于无认知功能障碍组[3.0(2.0-4.0) vs 1.0(1.0-2.0),P=0.012].认知功能障碍组的日常生活能力...

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Published in中国卒中杂志 Vol. 8; no. 6; pp. 459 - 463
Main Author 张娟 李见 陈文瑞 孟香玉 胡文立
Format Journal Article
LanguageChinese
Published 100020 北京首都医科大学附属北京朝阳医院神经内科 2013
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ISSN1673-5765

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Summary:目的研究急性脑梗死患者梗死部位及是否合并脑白质病变对患者早期认知功能的影响. 方法采用临床痴呆评定量表、简易精神状态检查量表和中文版蒙特利尔认知评估量表对连续入组的急性脑梗死患者进行认知心理学评估,分析患者不同梗死部位包括皮层梗死、皮层下关键部位梗死和皮层下非关键部位梗死及是否合并白质病变对患者认知功能的影响. 结果急性脑梗死患者血管性认知功能障碍组的平均年龄显著高于无认知功能障碍组(67.3110.88 vs 57.099.91,P=0.015),神经功能缺损评分显著高于无认知功能障碍组[3.0(2.0-4.0) vs 1.0(1.0-2.0),P=0.012].认知功能障碍组的日常生活能力评分显著低于无认知功能障碍组(81.6723.55 vs 95.9112.00,P=0.029).两组患者梗死部位有显著差异(P=0.042),皮层梗死更多见于血管性认知功能障碍组,皮层梗死患者的视空间与执行功能显著低于皮层下非关键位置梗死患者[1.5(0.0-3.0) vs 3.0(2.0-4.0),P=0.016].白质病变与认知障碍的发生无明显相关性. 结论急性脑梗死患者早期认知障碍与年龄、严重的神经功能缺损、皮层梗死、日常生活能力下降密切相关.
Bibliography:11-5434/R
Objective To analyze the influences of infarction locations and white matter lesions on vascular cognitive impairment (VCI) of acute cerebral infarction patients at their early stages. Methods Consecutive acute cerebral infarction patients underwent Clinical Dementia Rating (CDR), Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Analyses were performed to study the association between cognitive impairment and infarction locations including cortical infarction, subcortical critical site infarction, subcortical non-critical site infarction and white matter lesions including leukoaraiosis and non-leukoaraiosis. Results The mean age of cognitive impaired patients was significantly higher than that of normal cognition patients (67.31 10.88 vs 57.09 9.91, P=0.015). The mean score of National Institute of Health Stroke Scale (NIHSS) of cognitive impaired patients was significantly higher than that of normal cognition patients (3.0[2.0-4.0] vs 1.0[1.0-2.0], P=0.012). The mean sc
ISSN:1673-5765