Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis - Yang, Lin; Liu, Yanqing; Wang, Mei; Qian, Yayun; Dong, Xiaoyun; Gu, Hao; Wang, Haibo; Guo, Shiyu; Hisamitsu, Tadashi (Molecular medicine reports, 2016)
Keywords: Adaptor Proteins, Signal Transducing - biosynthesis; Adaptor Proteins, Signal Transducing - genetics; AKT protein; Apoptosis; Apoptosis - drug effects; B-cell lymphoma; Bcl-2 protein; Bcl-x protein; Carcinogenesis; Carcinogenesis - drug effects; Carcinogenesis - genetics; Care and treatment; Cell cycle; Cell Proliferation - drug effects; Cellular signal transduction; Chromatin; Colon cancer; Colonic Neoplasms - drug therapy; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Colorectal cancer; Colorectal carcinoma; COP9 Signalosome Complex; CSN6; Development and progression; Dose-Response Relationship, Drug; Electron microscopy; Flow cytometry; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Health aspects; HT-29 colon cancer cells; HT29 Cells; Humans; Kinases; Leukemia; Lymphocytes B; Lymphoma; Mammalian cells; MDM2 protein; Myc; Myc protein; p53 Protein; Phosphorylation; Photomorphogenesis; Protein expression; Proteins; Proto-Oncogene Proteins c-akt - biosynthesis; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-myc - biosynthesis; Proto-Oncogene Proteins c-myc - genetics; Quercetin; Quercetin - administration & dosage; Signal Transduction - drug effects; Studies; Transmission electron microscopy; Western blotting; United States--US