Reward and the serotonergic system

• Published in: Neuroscience Vol. 166; no. 4; pp. 1023 - 1035
• Main Authors: Kranz, G.S., Kasper, S., Lanzenberger, R.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 14.04.2010; Elsevier
• Subjects: Animals; Biological and medical sciences; Cognition - physiology; Emotions - physiology; Fundamental and applied biological sciences. Psychology; hedonia; Humans; intracranial self-stimulation; Models, Animal; motivation; Neural Pathways - anatomy & histology; Neural Pathways - metabolism; Neurology; Neurons - metabolism; pleasure; Pleasure - physiology; Primates; Raphe Nuclei - anatomy & histology; Raphe Nuclei - metabolism; Reward; Self Stimulation - physiology; serotonin; Serotonin - metabolism; Synaptic Transmission - physiology; Vertebrates: nervous system and sense organs; reward; ACC; DRN; VTA; pleasure; motivation; hedonia; 8-OH DPAT; MFB; MRN; OFC; intracranial self-stimulation; BP; SSRI; serotonin; NAcc; pCPA; ICSS; SN; 5-HT; PET; median raphe nucleus; 8-Hydroxy- N, N-dipropyl-2-aminotetralin; p-chlorophenylalanine; binding potential; selective serotonin reuptake inhibitor; orbitofrontal cortex; anterior cingulate cortex; substantia nigra; nucleus accumbens; dorsal raphe nucleus; medial forebrain bundle; ventral tegmental area; positron emission tomography; Serotonin; Neurotransmitter; Self stimulation; Reward

Anhedonia, as a failure to experience rewarding stimuli, is a key characteristic of many psychiatric disorders including depression and schizophrenia. Investigations on the neurobiological correlates of reward and hedonia/anhedonia have been a growing subject of research demonstrating several neurom...