Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study

• Published in: The lancet oncology Vol. 15; no. 13; pp. 1521 - 1532
• Main Authors: Lalonde, Emilie, MSc, Ishkanian, Adrian S, MD, Sykes, Jenna, MMath, Fraser, Michael, PhD, Ross-Adams, Helen, PhD, Erho, Nicholas, MSc, Dunning, Mark J, PhD, Halim, Silvia, MSc, Lamb, Alastair D, FRCS, Moon, Nathalie C, MMath, Zafarana, Gaetano, PhD, Warren, Anne Y, FRCPath, Meng, Xianyue, MSc, Thoms, John, MD, Grzadkowski, Michal R, BMath, Berlin, Alejandro, MD, Have, Cherry L, BSc, Ramnarine, Varune R, BCS, Yao, Cindy Q, MSc, Malloff, Chad A, MSc, Lam, Lucia L, BSc, Xie, Honglei, MMath, Harding, Nicholas J, PhD, Mak, Denise Y F, PhD, Chu, Kenneth C, PhD, Chong, Lauren C, BCS, Sendorek, Dorota H, BSc, P'ng, Christine, BSc, Collins, Colin C, Prof, Squire, Jeremy A, Prof, Jurisica, Igor, Prof, Cooper, Colin, PhD, Eeles, Rosalind, Prof, Pintilie, Melania, MSc, Dal Pra, Alan, MD, Davicioni, Elai, PhD, Lam, Wan L, Prof, Milosevic, Michael, MD, Neal, David E, Prof, van der Kwast, Theodorus, Prof, Boutros, Paul C, Prof, Bristow, Robert G, Prof
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2014; Elsevier Limited
• Subjects: Antigens; Biomarkers, Tumor - genetics; Biopsy; Cancer therapies; Deoxyribonucleic acid; DNA; DNA, Neoplasm - genetics; Follow-Up Studies; Gene Expression Profiling; Genomes; Genomics; Hematology, Oncology and Palliative Medicine; Humans; Hypoxia; Male; Men; Metastasis; Mortality; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - genetics; Oligonucleotide Array Sequence Analysis; Patients; Prognosis; Prostate cancer; Prostatic Neoplasms - genetics; Radiation therapy; Retrospective Studies; Time Factors; Tumor Microenvironment - genetics

Summary Background Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratificatio...