Cholesterol Metabolism in CKD

• Published in: American journal of kidney diseases Vol. 66; no. 6; pp. 1071 - 1082
• Main Authors: Reiss, Allison B., MD, Voloshyna, Iryna, PhD, De Leon, Joshua, MD, Miyawaki, Nobuyuki, MD, Mattana, Joseph, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2015
• Subjects: Animals; atherosclerosis; Biological Transport - physiology; cardiovascular disease (CVD); Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - metabolism; Cholesterol transport; Cholesterol, HDL - metabolism; chronic kidney disease (CKD); dyslipidemia; high-density lipoprotein (HDL); Humans; inflammation; lipid-lowering therapy; low-density lipoprotein (LDL); Nephrology; nontraditional risk factor; reactive oxygen species (ROS); Renal Insufficiency, Chronic - diagnosis; Renal Insufficiency, Chronic - epidemiology; Renal Insufficiency, Chronic - metabolism; Risk Factors; statin therapy; uremic toxins; Cholesterol transport; atherosclerosis; uremic toxins; reactive oxygen species (ROS); chronic kidney disease (CKD); nontraditional risk factor; statin therapy; lipid-lowering therapy; inflammation; dyslipidemia; low-density lipoprotein (LDL); cardiovascular disease (CVD); high-density lipoprotein (HDL)

Patients with chronic kidney disease (CKD) have a substantial risk of developing coronary artery disease. Traditional cardiovascular disease (CVD) risk factors such as hypertension and hyperlipidemia do not adequately explain the high prevalence of CVD in CKD. Both CVD and CKD are inflammatory state...