The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial

• Published in: BMC cancer Vol. 25; no. 1; pp. 344 - 9
• Main Authors: Eghbali, Aziz, Adibifar, Mahsa, Ghasemi, Ali, Afzal, Roghayeh Rahimi, Moradi, Katayoun, Eghbali, Aygin, Faress, Foroozan, Ghaffari, Kazem
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.02.2025; BioMed Central; BMC
• Subjects: Acute lymphoblastic leukemia; Acute lymphocytic leukemia; Administration, Oral; Adolescent; Antineoplastic Agents, Phytogenic - adverse effects; Antioxidants; Care and treatment; Causes of; Chemotherapy; Child; Child, Preschool; Clinical trials; Complications and side effects; Curcumin; Curcumin - administration & dosage; Curcumin - therapeutic use; Diabetes; Dosage and administration; Double-Blind Method; Drug therapy; Electromyography; Female; Humans; Leukemia; Lymphatic leukemia; Lymphoma; Male; Medical prognosis; Neurological diseases; Neuropathy; Oncology; Pain; Parents & parenting; Patients; Pediatric research; Pediatrics; Peripheral Nervous System Diseases - chemically induced; Peripheral Nervous System Diseases - drug therapy; Peripheral Nervous System Diseases - prevention & control; Peripheral neuropathy; Pharmaceutical industry; Placebos; Polyneuropathies; Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Sensory neurons; Spinal cord; Treatment Outcome; Turmeric; Vincristine; Vincristine - administration & dosage; Vincristine - adverse effects; Iran; Pediatrics; Curcumin; Neuropathy; Acute lymphoblastic leukemia; Vincristine

Peripheral neuropathy is a major adverse effect of Vincristine (VCR) in pediatric acute lymphoblastic leukemia (ALL) patients. Curcumin can prevent the development of many neurological diseases. This clinical trial study was conducted on 141 pediatric ALL patients, all over 5 years old. The subjects...