Identification and characterization of tumorigenic liver cancer stem/progenitor cells

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 132; no. 7; p. 2542
• Main Authors: Ma, Stephanie, Chan, Kwok-Wah, Hu, Liang, Lee, Terence Kin-Wah, Wo, Jana Yim-Hung, Ng, Irene Oi-Lin, Zheng, Bo-Jian, Guan, Xin-Yuan
• Format: Journal Article
• Language: English
• Published: United States 01.06.2007
• Subjects: AC133 Antigen; Animals; Antigens, CD - metabolism; Antigens, Differentiation - metabolism; Carcinogenicity Tests; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Differentiation; Cell Division; Cell Line, Tumor; Cell Separation; Gene Expression; Glycoproteins - metabolism; Humans; Liver - metabolism; Liver - pathology; Liver - physiopathology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Liver Regeneration; Mice; Mice, Nude; Mice, SCID; Muscle Development; Neoplasm Transplantation; Neovascularization, Pathologic; Peptides - metabolism; Phenotype; Stem Cells - metabolism; Stem Cells - pathology; Transplantation, Heterologous

Recent efforts in stem cell biology suggest that tumors are organized in a hierarchy of heterogeneous cell populations and that the capability to maintain tumor formation/growth specifically resides in a small population of cells called cancer stem cells (CSCs). The aim of this study is to identify,...