The representation of heart development in the gene ontology

• Published in: Developmental biology Vol. 354; no. 1; pp. 9 - 17
• Main Authors: Khodiyar, Varsha K., Hill, David P., Howe, Doug, Berardini, Tanya Z., Tweedie, Susan, Talmud, Philippa J., Breckenridge, Ross, Bhattarcharya, Shoumo, Riley, Paul, Scambler, Peter, Lovering, Ruth C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2011
• Subjects: Animals; Annotation; Cardiovascular; cardiovascular diseases; Cell Differentiation - genetics; community development; Computational Biology - methods; data collection; Databases, Genetic; Development; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Ontology; genes; Genetic Predisposition to Disease; Heart; Heart - embryology; Heart - growth & development; Heart Diseases - genetics; Heart Diseases - pathology; Humans; information retrieval; microarray technology; morphogenesis; Myocardium - cytology; Myocardium - metabolism; proteomics; research and development; signal transduction; Signal Transduction - genetics; stem cells; Vocabulary, Controlled; Heart; Development; Cardiovascular; Annotation; Gene Ontology

An understanding of heart development is critical in any systems biology approach to cardiovascular disease. The interpretation of data generated from high-throughput technologies (such as microarray and proteomics) is also essential to this approach. However, characterizing the role of genes in the...