Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex

• Published in: Acta neuropathologica Vol. 145; no. 4; pp. 439 - 459
• Main Authors: Matosin, Natalie, Arloth, Janine, Czamara, Darina, Edmond, Katrina Z., Maitra, Malosree, Fröhlich, Anna S., Martinelli, Silvia, Kaul, Dominic, Bartlett, Rachael, Curry, Amber R., Gassen, Nils C., Hafner, Kathrin, Müller, Nikola S., Worf, Karolina, Rehawi, Ghalia, Nagy, Corina, Halldorsdottir, Thorhildur, Cruceanu, Cristiana, Gagliardi, Miriam, Gerstner, Nathalie, Ködel, Maik, Murek, Vanessa, Ziller, Michael J., Scarr, Elizabeth, Tao, Ran, Jaffe, Andrew E., Arzberger, Thomas, Falkai, Peter, Kleinmann, Joel E., Weinberger, Daniel R., Mechawar, Naguib, Schmitt, Andrea, Dean, Brian, Turecki, Gustavo, Hyde, Thomas M., Binder, Elisabeth B.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2023; Springer; Springer Nature B.V
• Subjects: Aging; Aging - genetics; Bipolar disorder; Brain-derived neurotrophic factor; Cognitive ability; Dendritic spines; DNA microarrays; Drug development; Gene expression; Genetic aspects; Genotype; Genotype & phenotype; Genotypes; Health aspects; Humans; Immunohistochemistry; Medical colleges; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Mental disorders; Mental Disorders - genetics; mRNA; Neocortex; Neurons; Neurophysiology; Neurosciences; Original Paper; Pathology; Polymorphism, Single Nucleotide; Protein arrays; Psychology, Pathological; Psychopathology; RNA sequencing; Schizophrenia; Synaptic plasticity; Therapeutic targets; Psychosis; Ageing; Single cell; Depression; FKBP51; Postmortem brain; Stress; FKBP5

Identification and characterisation of novel targets for treatment is a priority in the field of psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a subset of psychiatric patients, with potential to be leveraged as a therapeutic target for these individuals. Whil...