The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology

• Published in: Cell reports (Cambridge) Vol. 29; no. 1; pp. 187 - 201.e7
• Main Authors: Wood, Thomas E., Howard, Sophie A., Förster, Andreas, Nolan, Laura M., Manoli, Eleni, Bullen, Nathan P., Yau, Hamish C.L., Hachani, Abderrahman, Hayward, Richard D., Whitney, John C., Vollmer, Waldemar, Freemont, Paul S., Filloux, Alain
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2019; Cell Press; Elsevier
• Subjects: Anti-Bacterial Agents - pharmacology; Bacterial Proteins - metabolism; Bacterial Secretion Systems - metabolism; Bacterial Secretion Systems - physiology; beta-Lactams - metabolism; effector; metallopeptidase; Periplasm - drug effects; Periplasm - metabolism; Periplasm - physiology; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - metabolism; Pseudomonas aeruginosa - physiology; type VI secretion system; Type VI Secretion Systems - metabolism; Type VI Secretion Systems - physiology; VgrG; Virulence Factors - metabolism; Pseudomonas aeruginosa; effector; type VI secretion system; metallopeptidase; VgrG

The type VI secretion system (T6SS) is crucial in interbacterial competition and is a virulence determinant of many Gram-negative bacteria. Several T6SS effectors are covalently fused to secreted T6SS structural components such as the VgrG spike for delivery into target cells. In Pseudomonas aerugin...