Glyoxalase-I mRNA expression and CCK-4 induced panic attacks

• Published in: Journal of psychiatric research Vol. 45; no. 1; pp. 60 - 63
• Main Authors: Eser, Daniela, Uhr, Manfred, Leicht, Gregor, Asmus, Maria, Länger, Anna, Schüle, Cornelius, Baghai, Thomas C., Mulert, Christoph, Rupprecht, Rainer
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.01.2011; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Anxiety; Anxiety disorders. Neuroses; Biological and medical sciences; CCK-4; Challenge paradigm; Gene expression; Gene Expression Regulation - drug effects; Glyoxalase-1; Heart rate; Humans; Induced; Lactoylglutathione Lyase - genetics; Lactoylglutathione Lyase - metabolism; Male; Medical sciences; Panic; Panic disorder; Panic Disorder - blood; Panic Disorder - chemically induced; Psychiatric Status Rating Scales; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; RNA, Messenger - metabolism; Severity; Tetragastrin - toxicity; Trait anxiety; Volunteers; Anxiety; Glyoxalase-1; CCK-4; Panic disorder; Challenge paradigm; Affect affectivity; Panic; Enzyme; Anxiety disorder; Lyases; Gene expression; Genetic determinism; Neuropeptide; Panic attack; Carbon-sulfur lyases; Genetics; Cholecystokinin; Lactoylglutathione lyase

There is evidence that the anti-glycation enzyme glyoxalase-1 (GLO1) may play a role in anxiety-related behaviour. However, discordant findings between GLO1 expression and anxiety-related behaviour have been observed in animal models. Because no data are available on the relation between GLO1 mRNA e...