Prognostic DNA methylation markers for prostate cancer

• Published in: International Journal of Molecular Sciences Vol. 15; no. 9; pp. 16544 - 16576
• Main Authors: Strand, Siri H, Orntoft, Torben F, Sorensen, Karina D
• Format: Journal Article Book Review
• Language: English
• Published: Switzerland MDPI AG 18.09.2014; MDPI
• Subjects: Adenocarcinoma - chemistry; Adenocarcinoma - genetics; Adenocarcinoma - mortality; biomarker; Biomarkers; Body Fluids - chemistry; DNA Methylation; DNA, Neoplasm - analysis; DNA, Neoplasm - chemistry; DNA, Neoplasm - genetics; Early Detection of Cancer; epigenetics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic - physiology; Humans; Male; MicroRNAs - genetics; Neoplasm Invasiveness - genetics; Neoplasm Proteins - genetics; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic - genetics; Prostate cancer; Prostatic Neoplasms - chemistry; Prostatic Neoplasms - genetics; Prostatic Neoplasms - mortality; Proteins - genetics; Review; RNA, Neoplasm - genetics

Prostate cancer (PC) is the most commonly diagnosed neoplasm and the third most common cause of cancer-related death amongst men in the Western world. PC is a clinically highly heterogeneous disease, and distinction between aggressive and indolent disease is a major challenge for the management of P...