A phase I study of single-agent BEZ235 special delivery system sachet in Japanese patients with advanced solid tumors - Toyoda, Masanori; Watanabe, Koichiro; Amagasaki, Taro; Natsume, Kazuto; Takeuchi, Hiromi; Quadt, Cornelia; Shirao, Kuniaki; Minami, Hironobu (Cancer chemotherapy and pharmacology, 2019)
Keywords: 1-Phosphatidylinositol 3-kinase; Adult; Aged; Antineoplastic Agents - therapeutic use; Appetite loss; Cancer Research; Diarrhea; Drug Delivery Systems; Enzyme inhibitors; Female; Follow-Up Studies; Humans; Hypersensitivity; Imidazoles - pharmacokinetics; Imidazoles - therapeutic use; Japan; Liver diseases; Male; Maximum Tolerated Dose; Medicine; Medicine & Public Health; Middle Aged; Nausea; Neoplasms - drug therapy; Neoplasms - pathology; Oncology; Original; Original Article; Pharmacodynamics; Pharmacology/Toxicology; Prognosis; Quinolines - pharmacokinetics; Quinolines - therapeutic use; Rapamycin; Solid tumors; Stomatitis; Thrombocytopenia; Tissue Distribution; TOR protein; Japan; mTOR; BEZ235; Inhibitor; Phase I; PI3K