Cytoplasmic kinases downstream of GPR30 suppress gonadotropin-releasing hormone (GnRH)-induced luteinizing hormone secretion from bovine anterior pituitary cells

• Published in: Journal of Reproduction and Development Vol. 62; no. 1; pp. 65 - 69
• Main Authors: RUDOLF, Faidiban O., KADOKAWA, Hiroya
• Format: Journal Article
• Language: English
• Published: Japan THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT 2016; The Society for Reproduction and Development
• Subjects: Animals; Butadienes - chemistry; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases - metabolism; Cyclopentanes - chemistry; Cytoplasm - enzymology; Estradiol - chemistry; Extra-cellular regulated kinases; G protein-coupled estrogen receptor-1; Gene Expression Regulation, Enzymologic; Gonadotrope; Gonadotropin-Releasing Hormone - antagonists & inhibitors; Gonadotropin-Releasing Hormone - chemistry; Isoquinolines - chemistry; Ligands; Luteinizing Hormone - metabolism; MAP Kinase Kinase Kinases - metabolism; Nitriles - chemistry; Original; Phosphorylation; Pituitary Gland, Anterior - drug effects; Pituitary Gland, Anterior - metabolism; Protein kinase A; Quinolines - chemistry; Receptors, G-Protein-Coupled - metabolism; Ruminant; Sulfonamides - chemistry

GPR30 is known as a membrane receptor for picomolar concentrations of estradiol. The GPR30-specific agonist G1 causes a rapid, non-genomic suppression of gonadotropin-releasing hormone (GnRH)-induced luteinizing hormone (LH) secretion from bovine anterior pituitary (AP) cells. A few studies have rec...