Aberrant extracellular signal-regulated kinase (ERK)1/2 signalling in suicide brain: role of ERK kinase 1 (MEK1)

• Published in: The international journal of neuropsychopharmacology Vol. 12; no. 10; pp. 1337 - 1354
• Main Authors: Dwivedi, Yogesh, Rizavi, Hooriyah S., Zhang, Hui, Roberts, Rosalinda C., Conley, Robert R., Pandey, Ghanshyam N.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.11.2009; Oxford University Press
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers - metabolism; Brain; Brain - enzymology; Brain - pathology; Catalytic Domain - physiology; Depressive Disorder, Major - enzymology; Depressive Disorder, Major - psychology; Down-Regulation - physiology; Female; Humans; Male; MAP Kinase Kinase 1 - biosynthesis; MAP Kinase Kinase 1 - metabolism; MAP Kinase Kinase 1 - physiology; MAP Kinase Signaling System - physiology; Middle Aged; Mitogen-Activated Protein Kinase 1 - biosynthesis; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 1 - physiology; Mitogen-Activated Protein Kinase 3 - biosynthesis; Mitogen-Activated Protein Kinase 3 - metabolism; Mitogen-Activated Protein Kinase 3 - physiology; Phosphorylation; Phosphorylation - physiology; Suicide - psychology; Suicides & suicide attempts; Up-Regulation - physiology; Young Adult; post-mortem brain; Depression; ERK kinase; ERK1/2 signalling; suicide

Extracellular signal-regulated kinase (ERK)1/2 signalling plays a critical role in synaptic and structural plasticity. Recent preclinical and human brain studies suggest that depression and suicidal behaviour are associated with aberrant ERK1/2 signalling. MEK, is a dual-specificity kinase, which is...