Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization

• Published in: Experimental Animals Vol. 71; no. 4; pp. 481 - 490
• Main Authors: Fang, Honglong, Luo, Jian, Lv, Liang, Zhang, Weiwen, Hu, Jianhua, Chen, Juan, Wang, Danqiong
• Format: Journal Article
• Language: English
• Published: Tokyo Japanese Association for Laboratory Animal Science 01.01.2022; Japan Science and Technology Agency
• Subjects: abietic acid; Attenuation; Bronchus; CD16 antigen; Cecum; Chains; Gene expression; IL-1β; Inflammation; Inflammatory response; Injury prevention; Interleukin 6; Lavage; Leukocytes (neutrophilic); Lipopolysaccharides; lung injury; Lungs; Lymphocytes B; macrophage; Macrophage inflammatory protein; Macrophages; NF-κB protein; Nitric-oxide synthase; nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB); Polarization; Proteins; Sepsis; Synaptotagmin; Tumor necrosis factor-α

Lung injury is one of the leading causes of death in sepsis. Abietic acid (AA) has demonstrated anti-inflammatory and bacteriostatic properties. Herein, we established a mouse model of sepsis by cecal ligation and puncture, and intraperitoneally injected AA to treat. Lung injury was assessed by H&am...