Identifying high-risk candidates for prolonging progression-free survival in primary gastric carcinoma subject to “double invasion”: an analytical approach utilizing lasso-cox regression

• Published in: BMC cancer Vol. 25; no. 1; pp. 381 - 16
• Main Authors: Wang, Liwei, Chang, Yu, Ma, Jinfeng, Qu, Wenqing, Li, Yifan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.02.2025; BioMed Central; BMC
• Subjects: Accuracy; Adult; Aged; Biomarkers; Calibration; Cancer invasiveness; Cancer therapies; Carcinoma; Chemotherapy; Complications and side effects; Datasets; Development and progression; Female; Gastrectomy; Gastric cancer; Gastrointestinal surgery; Health aspects; Hospitals; Humans; Lymph nodes; Lymphatic system; Male; Medical records; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Nomogram; Nomograms; Nomography (Mathematics); Patients; Prognosis; Progression-Free Survival; Proportional Hazards Models; PTEN protein; Retrospective Studies; Risk Assessment; Risk Factors; Risk groups; Risk stratification; ROC Curve; Statistical analysis; Stomach cancer; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Surgical outcomes; Variables; Vascular invasion and neural invasion; China; Gastric cancer; Progression-free survival; Nomogram; Risk stratification; Vascular invasion and neural invasion

To identify high-risk gastric carcinoma patients with concurrent vascular and neural invasion ("double invasion") who are at heightened risk of progression-free survival (PFS) decline, enabling personalized clinical management. In this multi-center retrospective study, 559 patients with do...