Magnetic properties and antitumor effect of nanocomplexes of iron oxide and doxorubicin

• Published in: Nanomedicine Vol. 11; no. 1; pp. 47 - 55
• Main Authors: Orel, Valerii, Dr, Shevchenko, Anatoliy, Dr, Romanov, Andriy, Ph.D, Tselepi, Marina, Dr, Mitrelias, Thanos, Dr, Barnes, Crispin H.W., Dr, Burlaka, Anatoliy, Dr, Lukin, Sergey, Dr, Shchepotin, Igor, Dr
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2015
• Subjects: Animals; Antineoplastic Agents - chemistry; Carcinoma, Lewis Lung; Cell Line, Tumor; Doxorubicin; Doxorubicin - administration & dosage; Doxorubicin - chemistry; Drug Carriers - chemistry; Electron Spin Resonance Spectroscopy; Ferric Compounds - chemistry; Free Radicals; Hyperthermia, Induced; Internal Medicine; Lewis lung carcinoma; Magnetic nanoparticles; Magnetics; Magnetite Nanoparticles - chemistry; Magneto-mechano-chemical synthesis; Male; Mice; Mice, Inbred C57BL; Mitochondria - metabolism; Nanotechnology - methods; Temperature; Lewis lung carcinoma; Free radicals; Magneto-mechano-chemical synthesis; Doxorubicin; Magnetic nanoparticles

Abstract We present a technology and magneto-mechanical milling chamber for the magneto-mechano-chemical synthesis (MMCS) of magneto-sensitive complex nanoparticles (MNC) comprising nanoparticles Fe3 O4 and anticancer drug doxorubicin (DOXO). Magnetic properties of MNC were studied with vibrating ma...