Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 134; no. 2; p. 568
• Main Authors: Puri, Puneet, Mirshahi, Faridoddin, Cheung, Onpan, Natarajan, Ramesh, Maher, James W, Kellum, John M, Sanyal, Arun J
• Format: Journal Article
• Language: English
• Published: United States 01.02.2008
• Subjects: Activating Transcription Factor 4 - metabolism; Activating Transcription Factor 6 - metabolism; Adult; Antigens, Differentiation - metabolism; Cell Cycle Proteins - metabolism; DNA-Binding Proteins - metabolism; eIF-2 Kinase - metabolism; Endoplasmic Reticulum - physiology; Endoribonucleases - metabolism; Eukaryotic Initiation Factor-2 - metabolism; Fatty Liver - metabolism; Fatty Liver - physiopathology; Female; Humans; Liver - metabolism; Liver - pathology; Liver - physiopathology; Male; MAP Kinase Kinase 4 - metabolism; Membrane Proteins - metabolism; Metabolic Syndrome - metabolism; Metabolic Syndrome - physiopathology; Middle Aged; Protein Folding; Protein Phosphatase 1; Protein Processing, Post-Translational - physiology; Protein-Serine-Threonine Kinases - metabolism; Regulatory Factor X Transcription Factors; Transcription Factor CHOP - metabolism; Transcription Factors - metabolism; X-Box Binding Protein 1
• ISSN: 1528-0012
• DOI: 10.1053/j.gastro.2007.10.039

Nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) are associated with known triggers of the unfolded protein response (UPR). The aims were to (1) evaluate the activity of UPR in NAFL and NASH and (2) correlate expression of UPR pathways with liver histology. Messenger RNA (mRNA...