Corneal Higher-Order Aberrations Measurements: Precision of SD-OCT/Placido Topography and Comparison with a Scheimpflug/Placido Topography in Eyes After Small-Incision Lenticule Extraction

• Published in: Ophthalmology and therapy Vol. 12; no. 3; pp. 1595 - 1610
• Main Authors: Ning, Rui, Huang, Xiaomin, Jin, Yili, Lei, Chak Seng, Ma, Xindi, Xu, Shuoyu, Xiahou, Jinxuan, Savini, Giacomo, Schiano-Lomoriello, Domenico, Wang, Xiaoying, Zhou, Xingtao, Huang, Jinhai
• Format: Journal Article
• Language: English
• Published: Cheshire Springer Healthcare 01.06.2023; Adis, Springer Healthcare
• Subjects: Agreement; Higher-order aberrations; Internal Medicine; Medicine; Medicine & Public Health; Ophthalmology; Optical coherence tomography-Placido; Original Research; Small-incision lenticule extraction; Higher-order aberrations; Small-incision lenticule extraction; Agreement; Optical coherence tomography-Placido
• ISSN: 2193-8245; 2193-6528
• DOI: 10.1007/s40123-023-00693-1

Introduction The aim of this study was to evaluate the measurements of corneal higher-order aberrations (HOAs) obtained by a new anterior segment optical coherence tomography (OCT) technique combined with a Placido topographer (the MS-39 device) in eyes with prior small-incision lenticule extraction (SMILE) and compare them to the measurements obtained by a Scheimpflug camera combined with a Placido topographer (the Sirius device). Methods A total of 56 eyes (56 patients) were included in this prospective study. Corneal aberrations were analyzed for the anterior, posterior, and total cornea surfaces. Within-subject standard deviation ( S w ), test–retest repeatability (TRT), and intraclass correlation coefficient (ICC) were used to assess the intraobserver repeatability and interobserver reproducibility. The differences were evaluated by paired t -test. Bland–Altman plots and 95% limits of agreement (95% LoA) were used to evaluate the agreement. Results High repeatability was observed for anterior and total corneal parameters, with S w value < 0.07, TRT ≤ 0.16, and ICCs > 0.893, but not trefoil. For the posterior corneal parameters, ICCs varied from 0.088 to 0.966. Regarding interobserver reproducibility, all S w values were ≤ 0.04 and TRT ≤ 0.11. ICCs ranged from 0.846 to 0.989, from 0.432 to 0.972, and from 0.798 to 0.985 for the anterior, total, and posterior corneal aberrations parameters, respectively. The mean difference in all aberrations was ≤ 0.05 μm. All parameters showed a narrow 95% LoA. Conclusion The MS-39 device achieved high precision in both anterior and total corneal measurements; the precision of posterior corneal higher-order RMS, astigmatism II, coma, and trefoil was lower. The two technologies used by the MS-39 and Sirius devices can be used interchangeably for measuring corneal HOAs after SMILE.