Short communication: Carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation

• Published in: International journal of nanomedicine Vol. 8; no. 1; pp. 731 - 736
• Main Authors: Leuba, Kohana D, Durmus, Naside Gozde, Taylor, Erik N, Webster, Thomas J
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2013; Taylor & Francis Ltd; Dove Press; Dove Medical Press
• Subjects: Analysis of Variance; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; antibacterial; Antibiotics; biofilm; Biofilms; Biofilms - drug effects; Carboxylic Acids - chemistry; Ferric oxide; iron oxide; Isocyanates - chemistry; Magnetite Nanoparticles - chemistry; medical device infection; Medical equipment; Microbial mats; nanoparticle; Nanoparticles; Original Research; Physiological aspects; Properties; S. aureus; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus - physiology; United States; iron oxide; nanoparticle; antibacterial; medical device infection; S. aureus; biofilm
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S38256

Biofilms formed by antibiotic resistant Staphylococcus aureus (S. aureus) continue to be a problem for medical devices. Antibiotic resistant bacteria (such as S. aureus) often complicate the treatment and healing of the patient, yet, medical devices are needed to heal such patients. Therefore, methods to treat these Biofilms once formed on medical devices are badly needed. Due to their small size and magnetic properties, superparamagnetic iron oxide nanoparticles (SPION) may be one possible material to penetrate Biofilms and kill or slow the growth of bacteria. In this study, SPION were functionalized with amine, carboxylate, and isocyanate functional groups to further improve their efficacy to disrupt the growth of S. aureus Biofilms. Without the use of antibiotics, results showed that SPION functionalized with carboxylate groups (followed by isocyanate then amine functional groups then unfunctionalized SPION) significantly disrupted Biofilms and retarded the growth of S. aureus compared to untreated Biofilms (by over 35% after 24 hours).