Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder

• Published in: Molecular psychiatry Vol. 11; no. 9; pp. 847 - 857
• Main Authors: Pickard, B S, Malloy, M P, Christoforou, A, Thomson, P A, Evans, K L, Morris, S W, Hampson, M, Porteous, D J, Blackwood, D H R, Muir, W J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2006; Nature Publishing Group
• Subjects: Adult and adolescent clinical studies; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Bipolar disorder; Bipolar Disorder - genetics; Bipolar disorders; Breakpoints; Cells, Cultured; Chromosome rearrangements; Chromosomes; Chromosomes, Human, Pair 2 - genetics; Cytogenetics; DNA Primers; Exons; Female; Gene polymorphism; Gene Rearrangement; Genes; Glutamic acid receptors (ionotropic); Haplotypes; Humans; Hypotheses; Illnesses; In Situ Hybridization, Fluorescence; Intellectual disabilities; Intellectual Disability - genetics; Karyotyping; Learning disabilities; Medical sciences; Medicine; Medicine & Public Health; Mental disorders; Mood disorders; Neurosciences; Neurotransmission; original-article; Patients; Pharmacotherapy; Polymerase Chain Reaction; Polymorphism; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychosis; Receptors, Kainic Acid - genetics; Schizophrenia; Schizophrenia - genetics; Single-nucleotide polymorphism; Translocation, Genetic; United Kingdom > UK; United States > US; chromosome abnormality; haplotype; psychiatry; glutamate receptor; association study; Mood disorder; Schizophrenia; Bipolar disorder; Glutamate receptor; Genetic determinism; Kainate receptor; Psychosis; Gene; Cytogenetics; Genetics; Haplotype; Psychiatry

In the search for the biological causes of schizophrenia and bipolar disorder, glutamate neurotransmission has emerged as one of a number of candidate processes and pathways where underlying gene deficits may be present. The analysis of chromosomal rearrangements in individuals diagnosed with neurop...