Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer’s disease

• Published in: European journal of nuclear medicine and molecular imaging Vol. 46; no. 5; pp. 1152 - 1163
• Main Authors: Leuzy, Antoine, Cicognola, Claudia, Chiotis, Konstantinos, Saint-Aubert, Laure, Lemoine, Laetitia, Andreasen, Niels, Zetterberg, Henrik, Ye, Keqiang, Blennow, Kaj, Höglund, Kina, Nordberg, Agneta
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2019; Springer Nature B.V; Springer Verlag (Germany) [1976-....]
• Subjects: [F-18]FDG; [F-18]THK5317; Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Alzheimer's disease; Assaying; association; Biomarkers; Cardiology; Cerebrospinal fluid; CSF; Dementia; Dementia disorders; deposition; Female; fluid amyloid-beta; Fluorine isotopes; Fluorodeoxyglucose F18; Glucose; Glucose metabolism; human brain; Humans; Hypometabolism; Imaging; Life Sciences; Longitudinal Studies; Male; Medicine; Medicine & Public Health; Metabolism; Middle Aged; N-Terminus; Neurodegeneration; neurofibrillary pathology; Nuclear Medicine; Nuclear Medicine & Medical Imaging; Oncology; Original; Original Article; Orthopedics; PET imaging; phospho-tau; Phosphorylation; Positron emission; Positron emission tomography; Radiologi och bildbehandling; Radiology; Radiology and Medical Imaging; Tau; Tau protein; tau Proteins - cerebrospinal fluid; Threonine; Tomography; F]THK5317; Alzheimer’s disease; PET imaging; CSF; F]FDG; Tau; [; [18F]THK5317; [18F]FDG

Purpose Studies comparing CSF and PET tau biomarkers have included only commercial CSF assays examining specific phosphorylation sites (e.g. threonine 181, P-tau 181p ) and mid-domain tau (i.e. total tau, T-tau). Moreover, these studies did not examine CSF tau levels in relation to cerebral glucose...