Involvement of Fcα/μR (CD351) in autoantibody production

•Fcα/μR enhances, rather than suppresses, autoantibody production.•Fcα/μR on the MRL/MpJ-Faslpr/lpr background mice decreased survival rate.•IgM prevents autoantibody production independently with Fcα/μR expression. Antibody exerts various immune responses via binding to Fc receptors expressed on im...

Full description

Saved in:
Bibliographic Details
Published inMolecular immunology Vol. 57; no. 2; pp. 216 - 219
Main Authors Yoshizawa, Yuichi, Honda, Shin-ichiro, Shibuya, Akira
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2014
Elsevier
Subjects
Animals
antibody formation
autoantibodies
Autoantibodies - biosynthesis
Autoantibodies - blood
Autoantibodies - immunology
Autoantibody
cardiolipins
Cardiolipins - immunology
dendritic cells
Dendritic Cells, Follicular - metabolism
DNA
DNA - immunology
Fc receptor
histones
Histones - immunology
IgM
immunoglobulin A
Immunoglobulin A - immunology
immunoglobulin G
immunoglobulin M
Immunoglobulin M - immunology
Mice
Mice, Inbred BALB C
Mice, Knockout
receptors
Receptors, Fc - immunology
survival rate
Autoantibody
IgM
Fc receptor
Online AccessGet full text
ISSN0161-5890
1872-9142
1872-9142
DOI10.1016/j.molimm.2013.10.002

Cover

Abstract •Fcα/μR enhances, rather than suppresses, autoantibody production.•Fcα/μR on the MRL/MpJ-Faslpr/lpr background mice decreased survival rate.•IgM prevents autoantibody production independently with Fcα/μR expression. Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcα/μR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcα/μR on the background of MRL/MpJ-Faslpr/lpr (Fcamr−/−Faslpr/lpr) mice. Fcamr−/−Faslpr/lpr mice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than did Fcamr+/+Faslpr/lpr mice. Moreover, Fcamr−/−Faslpr/lpr mice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared with Fcamr+/+Faslpr/lpr mice. These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production.
AbstractList Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcα/μR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcα/μR on the background of MRL/MpJ-Faslpr/lpr (Fcamr−/−Faslpr/lpr) mice. Fcamr−/−Faslpr/lpr mice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than did Fcamr+/+Faslpr/lpr mice. Moreover, Fcamr−/−Faslpr/lpr mice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared with Fcamr+/+Faslpr/lpr mice. These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production.
Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcα/μR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcα/μR on the background of MRL/MpJ-Fas(lpr/lpr) (Fcamr(-/-)Fas(lpr/lpr)) mice. Fcamr(-/-)Fas(lpr/lpr) mice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than did Fcamr(+/+)Fas(lpr/lpr) mice. Moreover, Fcamr(-/-)Fas(lpr/lpr) mice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared with Fcamr(+/+)Fas(lpr/lpr) mice. These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production.
Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcα/μR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcα/μR on the background of MRL/MpJ-Fas(lpr/lpr) (Fcamr(-/-)Fas(lpr/lpr)) mice. Fcamr(-/-)Fas(lpr/lpr) mice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than did Fcamr(+/+)Fas(lpr/lpr) mice. Moreover, Fcamr(-/-)Fas(lpr/lpr) mice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared with Fcamr(+/+)Fas(lpr/lpr) mice. These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production.Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcα/μR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcα/μR on the background of MRL/MpJ-Fas(lpr/lpr) (Fcamr(-/-)Fas(lpr/lpr)) mice. Fcamr(-/-)Fas(lpr/lpr) mice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than did Fcamr(+/+)Fas(lpr/lpr) mice. Moreover, Fcamr(-/-)Fas(lpr/lpr) mice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared with Fcamr(+/+)Fas(lpr/lpr) mice. These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production.
•Fcα/μR enhances, rather than suppresses, autoantibody production.•Fcα/μR on the MRL/MpJ-Faslpr/lpr background mice decreased survival rate.•IgM prevents autoantibody production independently with Fcα/μR expression. Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcα/μR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcα/μR on the background of MRL/MpJ-Faslpr/lpr (Fcamr−/−Faslpr/lpr) mice. Fcamr−/−Faslpr/lpr mice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than did Fcamr+/+Faslpr/lpr mice. Moreover, Fcamr−/−Faslpr/lpr mice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared with Fcamr+/+Faslpr/lpr mice. These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production.
Author Shibuya, Akira
Yoshizawa, Yuichi
Honda, Shin-ichiro
Author_xml – sequence: 1
  givenname: Yuichi
  surname: Yoshizawa
  fullname: Yoshizawa, Yuichi
  organization: Department of Immunology, Institute of Basic Medical Sciences, Faculty of Medicine, Tsukuba, Japan
– sequence: 2
  givenname: Shin-ichiro
  surname: Honda
  fullname: Honda, Shin-ichiro
  email: shonda@md.tsukuba.ac.jp
  organization: Department of Immunology, Institute of Basic Medical Sciences, Faculty of Medicine, Tsukuba, Japan
– sequence: 3
  givenname: Akira
  surname: Shibuya
  fullname: Shibuya, Akira
  email: ashibuya@md.tsukuba.ac.jp
  organization: Department of Immunology, Institute of Basic Medical Sciences, Faculty of Medicine, Tsukuba, Japan
BackLink https://cir.nii.ac.jp/crid/1572543027502621824$$DView record in CiNii
https://www.ncbi.nlm.nih.gov/pubmed/24172225$$D View this record in MEDLINE/PubMed
BookMark eNqFkc9q3DAQxkVJaTZJ36AUH3pIDt6MxpJt5RAIm6YNBAqhPQut_oAWW0oteyGPlXufIc9UGSeXHpqLBMPvm5lvviNyEGKwhHyisKZA6_Pduo-d7_s1Aq1yaQ2A78iKtg2WgjI8IKuM0ZK3Ag7JUUo7AKih5h_IITLaICJfkYvbsI_d3vY2jEV0xY1-fjp__nNfnG6uK07PCh8KNY1RhdFvo3ksHoZoJj36GE7Ie6e6ZD--_Mfk183Xn5vv5d2Pb7ebq7tS8xbGkjtQNRpnUFTgmLatoYojtwo1OtGymnGFSLUQXGzBGKEq14iGQSW2jLrqmJwuffPo35NNo-x90rbrVLBxShKzL6yzZXgTpazGqqGC8Yx-fkGnbW-NfBh8r4ZH-XqaDFwsgB5iSoN1UvtRzcbHQflOUpBzDnInlxzknMNczdtkMftH_Nr_DdmXRRa8z-Pml_IGOasAG55dIm2RZexywWw--97bQSbtbdDW-MHqUZro_z_nLxFGq-c
CitedBy_id crossref_primary_10_3892_mmr_2022_12727
crossref_primary_10_1002_eji_202149383
crossref_primary_10_1186_s12979_022_00316_6
crossref_primary_10_3390_nu13031000
Cites_doi 10.1016/j.molimm.2009.10.016
10.1002/1521-4141(200105)31:5<1310::AID-IMMU1310>3.0.CO;2-N
10.1016/S0161-5890(01)00025-6
10.1016/j.bbrc.2006.04.084
10.1016/j.molimm.2013.04.003
10.1016/j.immuni.2005.12.008
10.1038/nri856
10.1073/pnas.1210706109
10.1073/pnas.97.3.1184
10.1084/jem.20050338
10.1016/S0952-7915(97)80168-9
10.1016/j.immuni.2008.06.009
10.1038/80886
10.1073/pnas.0809917106
10.1016/j.immuni.2013.02.023
10.1038/nri1456
10.1084/jem.20091107
10.1126/science.286.5447.2156
10.1093/intimm/dxp121
10.1084/jem.188.12.2381
10.1016/S1074-7613(03)00323-6
10.1146/annurev.immunol.15.1.203
10.1038/416603a
10.1016/j.molimm.2011.11.010
10.1084/jem.20062567
10.1146/annurev.immunol.16.1.421
10.1016/j.coi.2005.03.003
10.1084/jem.191.7.1253
10.1111/j.1365-2567.2004.02075.x
10.1084/jem.20092401
ContentType Journal Article
Copyright 2013 Elsevier Ltd
Copyright © 2013 Elsevier Ltd. All rights reserved.
Copyright_xml – notice: 2013 Elsevier Ltd
– notice: Copyright © 2013 Elsevier Ltd. All rights reserved.
DBID RYH
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
DOI 10.1016/j.molimm.2013.10.002
DatabaseName CiNii Complete
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList AGRICOLA
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Biology
EISSN 1872-9142
EndPage 219
ExternalDocumentID 24172225
10_1016_j_molimm_2013_10_002
120007130578
S0161589013005282
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
--K
--M
-~X
.55
.GJ
.~1
0R~
123
1B1
1RT
1~.
1~5
29M
3O-
4.4
457
4G.
53G
5RE
5VS
7-5
71M
8P~
9JM
AAAJQ
AABNK
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AARKO
AAXUO
ABBQC
ABEFU
ABFNM
ABFRF
ABGSF
ABJNI
ABLVK
ABMAC
ABMZM
ABOCM
ABUDA
ABXDB
ABYKQ
ACDAQ
ACGFO
ACGFS
ACIUM
ACNCT
ACRLP
ADBBV
ADEZE
ADMUD
ADUVX
AEBSH
AEFWE
AEHWI
AEKER
AENEX
AFFNX
AFKWA
AFTJW
AFXIZ
AGEKW
AGHFR
AGRDE
AGUBO
AGYEJ
AHHHB
AHPSJ
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AJRQY
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
BNPGV
C45
CJTIS
CNWQP
CS3
DOVZS
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HMG
HVGLF
HZ~
H~9
IH2
IHE
J1W
K-O
KOM
L7B
LCYCR
LUGTX
M41
MO0
N9A
O-L
O9-
OAUVE
OVD
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
ROL
RPZ
SDF
SDG
SDP
SES
SEW
SIN
SPCBC
SSH
SSI
SSU
SSZ
T5K
TEORI
UNMZH
WUQ
X7M
Y6R
ZA5
ZGI
~G-
AAHBH
AATTM
AAXKI
AAYWO
ACIEU
ACVFH
ADCNI
AEIPS
AEUPX
AFPUW
AGCQF
AGRNS
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
RYH
AAYXX
ABWVN
ACRPL
ADNMO
AFJKZ
AGQPQ
AIGII
APXCP
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
EFKBS
7S9
L.6
ID FETCH-LOGICAL-c580t-5f0a62dfd2930f4ce8d1a525ea2c2f984645a221c9959b0dd9a3f7974039b41f3
IEDL.DBID AIKHN
ISSN 0161-5890
1872-9142
IngestDate Fri Sep 05 08:39:02 EDT 2025
Thu Sep 04 23:56:14 EDT 2025
Thu Apr 03 07:04:12 EDT 2025
Tue Jul 01 01:57:09 EDT 2025
Thu Apr 24 22:59:17 EDT 2025
Thu Jun 26 23:15:22 EDT 2025
Fri Feb 23 02:27:03 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords Autoantibody
IgM
Fc receptor
Language English
License Copyright © 2013 Elsevier Ltd. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c580t-5f0a62dfd2930f4ce8d1a525ea2c2f984645a221c9959b0dd9a3f7974039b41f3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink http://hdl.handle.net/2241/120664
PMID 24172225
PQID 1462371945
PQPubID 23479
PageCount 4
ParticipantIDs proquest_miscellaneous_2000269140
proquest_miscellaneous_1462371945
pubmed_primary_24172225
crossref_citationtrail_10_1016_j_molimm_2013_10_002
crossref_primary_10_1016_j_molimm_2013_10_002
nii_cinii_1572543027502621824
elsevier_sciencedirect_doi_10_1016_j_molimm_2013_10_002
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate February 2014
20140201
2014-02-00
2014-Feb
PublicationDateYYYYMMDD 2014-02-01
PublicationDate_xml – month: 02
  year: 2014
  text: February 2014
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Molecular immunology
PublicationTitleAlternate Mol Immunol
PublicationYear 2014
Publisher Elsevier Ltd
Elsevier
Publisher_xml – name: Elsevier Ltd
– name: Elsevier
References Boes (bib0005) 2000; 37
Heesters, Chatterjee, Kim, Gonzalez, Kuligowski, Kirchhausen, Carroll (bib0060) 2013; 38
Ehrenstein, Cook, Neuberger (bib0050) 2000; 191
Kubagawa, Oka, Kubagawa, Torii, Takayama, Kang, Gartland, Bertoli, Mori, Takatsu, Kitamura, Ohno, Wang (bib0080) 2009; 206
Ouchida, Mori, Hase, Takatsu, Kurosaki, Tokuhisa, Ohno, Wang (bib0095) 2012; 109
Carroll (bib0020) 2004; 4
Cho, Usui, Honda, Tahara-Hanaoka, Shibuya, Shibuya (bib0035) 2006; 345
Takai (bib0140) 2002; 2
Christensen, Kashgarian, Alexopoulou, Flavell, Akira, Shlomchik (bib0040) 2005; 202
Ravetch, Clynes (bib0115) 1998; 16
Honda, Kurita, Miyamoto, Cho, Usui, Takeshita, Takahashi, Yasui, Kikutani, Kinoshita, Fujita, Tahara-Hanaoka, Shibuya, Shibuya (bib0070) 2009; 106
Leadbetter, Rifkin, Hohlbaum, Beaudette, Shlomchik, Marshak-Rothstein (bib0085) 2002; 416
Boes, Prodeus, Schmidt, Carroll, Chen (bib0010) 1998; 188
Takagaki, Satoh, Honda, Shibuya (bib0135) 2013; 56
Groom, Fletcher, Walters, Grey, Watt, Sweet, Smyth, Mackay, Mackay (bib0055) 2007; 204
Park, Choi (bib0100) 2005; 114
Ravetch (bib0110) 1997; 9
Viglianti, Lau, Hanley, Miko, Shlomchik, Marshak-Rothstein (bib0150) 2003; 19
Cho, Honda, Yoshizawa, Takagaki, Usui, Shibuya (bib0030) 2010; 47
Usui, Honda, Yoshizawa, Nakahashi-Oda, Tahara-Hanaoka, Shibuya, Shibuya (bib0145) 2012; 50
Boes, Schmidt, Linkemann, Beaudette, Marshak-Rothstein, Chen (bib0015) 2000; 97
Herlands, Christensen, Sweet, Hershberg, Shlomchik (bib0065) 2008; 29
Daeron (bib0045) 1997; 15
Chaplin, Zindl (bib0025) 2006; 24
Peng (bib0105) 2005; 17
Sakamoto, Shibuya, Shimizu, Yotsumoto, Miyabayashi, Sakano, Tsuji, Nakayama, Nakauchi, Shibuya (bib0120) 2001; 31
Shima, Takatsu, Fukuda, Ohmae, Hase, Kubagawa, Wang, Ohno (bib0130) 2010; 22
Kranich, Krautler, Falsig, Ballmer, Li, Hutter, Schwarz, Moos, Julius, Miele, Aguzzi (bib0075) 2010; 207
Ochsenbein, Fehr, Lutz, Suter, Brombacher, Hengartner, Zinkernagel (bib0090) 1999; 286
Shibuya, Sakamoto, Shimizu, Shibuya, Osawa, Hiroyama, Eyre, Sutherland, Endo, Fujita, Miyabayashi, Sakano, Tsuji, Nakayama, Phillips, Lanier, Nakauchi (bib0125) 2000; 1
Herlands (10.1016/j.molimm.2013.10.002_bib0065) 2008; 29
Ravetch (10.1016/j.molimm.2013.10.002_bib0110) 1997; 9
Boes (10.1016/j.molimm.2013.10.002_bib0010) 1998; 188
Christensen (10.1016/j.molimm.2013.10.002_bib0040) 2005; 202
Chaplin (10.1016/j.molimm.2013.10.002_bib0025) 2006; 24
Ravetch (10.1016/j.molimm.2013.10.002_bib0115) 1998; 16
Ehrenstein (10.1016/j.molimm.2013.10.002_bib0050) 2000; 191
Cho (10.1016/j.molimm.2013.10.002_bib0030) 2010; 47
Kranich (10.1016/j.molimm.2013.10.002_bib0075) 2010; 207
Peng (10.1016/j.molimm.2013.10.002_bib0105) 2005; 17
Usui (10.1016/j.molimm.2013.10.002_bib0145) 2012; 50
Sakamoto (10.1016/j.molimm.2013.10.002_bib0120) 2001; 31
Shibuya (10.1016/j.molimm.2013.10.002_bib0125) 2000; 1
Leadbetter (10.1016/j.molimm.2013.10.002_bib0085) 2002; 416
Groom (10.1016/j.molimm.2013.10.002_bib0055) 2007; 204
Park (10.1016/j.molimm.2013.10.002_bib0100) 2005; 114
Viglianti (10.1016/j.molimm.2013.10.002_bib0150) 2003; 19
Ochsenbein (10.1016/j.molimm.2013.10.002_bib0090) 1999; 286
Daeron (10.1016/j.molimm.2013.10.002_bib0045) 1997; 15
Boes (10.1016/j.molimm.2013.10.002_bib0005) 2000; 37
Shima (10.1016/j.molimm.2013.10.002_bib0130) 2010; 22
Takai (10.1016/j.molimm.2013.10.002_bib0140) 2002; 2
Cho (10.1016/j.molimm.2013.10.002_bib0035) 2006; 345
Honda (10.1016/j.molimm.2013.10.002_bib0070) 2009; 106
Ouchida (10.1016/j.molimm.2013.10.002_bib0095) 2012; 109
Takagaki (10.1016/j.molimm.2013.10.002_bib0135) 2013; 56
Heesters (10.1016/j.molimm.2013.10.002_bib0060) 2013; 38
Boes (10.1016/j.molimm.2013.10.002_bib0015) 2000; 97
Carroll (10.1016/j.molimm.2013.10.002_bib0020) 2004; 4
Kubagawa (10.1016/j.molimm.2013.10.002_bib0080) 2009; 206
References_xml – volume: 37
  start-page: 1141
  year: 2000
  end-page: 1149
  ident: bib0005
  article-title: Role of natural and immune IgM antibodies in immune responses
  publication-title: Mol. Immunol.
– volume: 4
  start-page: 825
  year: 2004
  end-page: 831
  ident: bib0020
  article-title: A protective role for innate immunity in systemic lupus erythematosus
  publication-title: Nat. Rev. Immunol.
– volume: 50
  start-page: 172
  year: 2012
  end-page: 176
  ident: bib0145
  article-title: Isolation and characterization of naive follicular dendritic cells
  publication-title: Mol. Immunol.
– volume: 97
  start-page: 1184
  year: 2000
  end-page: 1189
  ident: bib0015
  article-title: Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 109
  start-page: 2699
  year: 2012
  end-page: 2706
  ident: bib0095
  article-title: Critical role of the IgM Fc receptor in IgM homeostasis B-cell survival, and humoral immune responses
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 204
  start-page: 1959
  year: 2007
  end-page: 1971
  ident: bib0055
  article-title: BAFF and MyD88 signals promote a lupuslike disease independent of T cells
  publication-title: J. Exp. Med.
– volume: 207
  start-page: 2271
  year: 2010
  end-page: 2281
  ident: bib0075
  article-title: Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner
  publication-title: J. Exp. Med.
– volume: 29
  start-page: 249
  year: 2008
  end-page: 260
  ident: bib0065
  article-title: T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells
  publication-title: Immunity
– volume: 31
  start-page: 1310
  year: 2001
  end-page: 1316
  ident: bib0120
  article-title: A novel Fc receptor for IgA and IgM is expressed on both hematopoietic and non-hematopoietic tissues
  publication-title: Eur. J. Immunol.
– volume: 47
  start-page: 878
  year: 2010
  end-page: 882
  ident: bib0030
  article-title: Requirement of the cytoplasmic portion for dimer formation of Fcα/μ receptor expressed on cell surface
  publication-title: Mol. Immunol.
– volume: 345
  start-page: 474
  year: 2006
  end-page: 478
  ident: bib0035
  article-title: Molecular characteristics of IgA and IgM Fc binding to the Fcα/μR
  publication-title: Biochem. Biophys. Res. Commun.
– volume: 15
  start-page: 203
  year: 1997
  end-page: 234
  ident: bib0045
  article-title: Fc receptor biology
  publication-title: Annu. Rev. Immunol.
– volume: 188
  start-page: 2381
  year: 1998
  end-page: 2386
  ident: bib0010
  article-title: A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection
  publication-title: J. Exp. Med.
– volume: 19
  start-page: 837
  year: 2003
  end-page: 847
  ident: bib0150
  article-title: Activation of autoreactive B cells by CpG dsDNA
  publication-title: Immunity
– volume: 286
  start-page: 2156
  year: 1999
  end-page: 2159
  ident: bib0090
  article-title: Control of early viral and bacterial distribution and disease by natural antibodies
  publication-title: Science
– volume: 114
  start-page: 2
  year: 2005
  end-page: 10
  ident: bib0100
  article-title: How do follicular dendritic cells interact intimately with B cells in the germinal centre?
  publication-title: Immunology
– volume: 17
  start-page: 230
  year: 2005
  end-page: 236
  ident: bib0105
  article-title: Signaling in B cells via Toll-like receptors
  publication-title: Curr. Opin. Immunol.
– volume: 24
  start-page: 13
  year: 2006
  end-page: 15
  ident: bib0025
  article-title: Taking control of follicular dendritic cells
  publication-title: Immunity
– volume: 202
  start-page: 321
  year: 2005
  end-page: 331
  ident: bib0040
  article-title: Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
  publication-title: J. Exp. Med.
– volume: 1
  start-page: 441
  year: 2000
  end-page: 446
  ident: bib0125
  article-title: Fcα/μ receptor mediates endocytosis of IgM-coated microbes
  publication-title: Nat. Immunol.
– volume: 416
  start-page: 603
  year: 2002
  end-page: 607
  ident: bib0085
  article-title: Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
  publication-title: Nature
– volume: 38
  start-page: 1164
  year: 2013
  end-page: 1175
  ident: bib0060
  article-title: Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation
  publication-title: Immunity
– volume: 22
  start-page: 149
  year: 2010
  end-page: 156
  ident: bib0130
  article-title: Identification of TOSO/FAIM3 as an Fc receptor for IgM
  publication-title: Int. Immunol.
– volume: 191
  start-page: 1253
  year: 2000
  end-page: 1258
  ident: bib0050
  article-title: Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies
  publication-title: J. Exp. Med.
– volume: 9
  start-page: 121
  year: 1997
  end-page: 125
  ident: bib0110
  article-title: Fc receptors
  publication-title: Curr. Opin. Immunol.
– volume: 2
  start-page: 580
  year: 2002
  end-page: 592
  ident: bib0140
  article-title: Roles of Fc receptors in autoimmunity
  publication-title: Nat. Rev. Immunol.
– volume: 106
  start-page: 11230
  year: 2009
  end-page: 11235
  ident: bib0070
  article-title: Enhanced humoral immune responses against T-independent antigens in Fcα/μR-deficient mice
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 206
  start-page: 2779
  year: 2009
  end-page: 2793
  ident: bib0080
  article-title: Identity of the elusive IgM Fc receptor (FcμR) in humans
  publication-title: J. Exp. Med.
– volume: 16
  start-page: 421
  year: 1998
  end-page: 432
  ident: bib0115
  article-title: Divergent roles for Fc receptors and complement in vivo
  publication-title: Annu. Rev. Immunol.
– volume: 56
  start-page: 23
  year: 2013
  end-page: 27
  ident: bib0135
  article-title: Molecular characterization of the dimer formation of Fcα/μ receptor (CD351)
  publication-title: Mol. Immunol.
– volume: 47
  start-page: 878
  year: 2010
  ident: 10.1016/j.molimm.2013.10.002_bib0030
  article-title: Requirement of the cytoplasmic portion for dimer formation of Fcα/μ receptor expressed on cell surface
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2009.10.016
– volume: 31
  start-page: 1310
  year: 2001
  ident: 10.1016/j.molimm.2013.10.002_bib0120
  article-title: A novel Fc receptor for IgA and IgM is expressed on both hematopoietic and non-hematopoietic tissues
  publication-title: Eur. J. Immunol.
  doi: 10.1002/1521-4141(200105)31:5<1310::AID-IMMU1310>3.0.CO;2-N
– volume: 37
  start-page: 1141
  year: 2000
  ident: 10.1016/j.molimm.2013.10.002_bib0005
  article-title: Role of natural and immune IgM antibodies in immune responses
  publication-title: Mol. Immunol.
  doi: 10.1016/S0161-5890(01)00025-6
– volume: 345
  start-page: 474
  year: 2006
  ident: 10.1016/j.molimm.2013.10.002_bib0035
  article-title: Molecular characteristics of IgA and IgM Fc binding to the Fcα/μR
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2006.04.084
– volume: 56
  start-page: 23
  year: 2013
  ident: 10.1016/j.molimm.2013.10.002_bib0135
  article-title: Molecular characterization of the dimer formation of Fcα/μ receptor (CD351)
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2013.04.003
– volume: 24
  start-page: 13
  year: 2006
  ident: 10.1016/j.molimm.2013.10.002_bib0025
  article-title: Taking control of follicular dendritic cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2005.12.008
– volume: 2
  start-page: 580
  year: 2002
  ident: 10.1016/j.molimm.2013.10.002_bib0140
  article-title: Roles of Fc receptors in autoimmunity
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri856
– volume: 109
  start-page: 2699
  year: 2012
  ident: 10.1016/j.molimm.2013.10.002_bib0095
  article-title: Critical role of the IgM Fc receptor in IgM homeostasis B-cell survival, and humoral immune responses
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1210706109
– volume: 97
  start-page: 1184
  year: 2000
  ident: 10.1016/j.molimm.2013.10.002_bib0015
  article-title: Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.97.3.1184
– volume: 202
  start-page: 321
  year: 2005
  ident: 10.1016/j.molimm.2013.10.002_bib0040
  article-title: Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20050338
– volume: 9
  start-page: 121
  year: 1997
  ident: 10.1016/j.molimm.2013.10.002_bib0110
  article-title: Fc receptors
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/S0952-7915(97)80168-9
– volume: 29
  start-page: 249
  year: 2008
  ident: 10.1016/j.molimm.2013.10.002_bib0065
  article-title: T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2008.06.009
– volume: 1
  start-page: 441
  year: 2000
  ident: 10.1016/j.molimm.2013.10.002_bib0125
  article-title: Fcα/μ receptor mediates endocytosis of IgM-coated microbes
  publication-title: Nat. Immunol.
  doi: 10.1038/80886
– volume: 106
  start-page: 11230
  year: 2009
  ident: 10.1016/j.molimm.2013.10.002_bib0070
  article-title: Enhanced humoral immune responses against T-independent antigens in Fcα/μR-deficient mice
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0809917106
– volume: 38
  start-page: 1164
  year: 2013
  ident: 10.1016/j.molimm.2013.10.002_bib0060
  article-title: Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.02.023
– volume: 4
  start-page: 825
  year: 2004
  ident: 10.1016/j.molimm.2013.10.002_bib0020
  article-title: A protective role for innate immunity in systemic lupus erythematosus
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri1456
– volume: 206
  start-page: 2779
  year: 2009
  ident: 10.1016/j.molimm.2013.10.002_bib0080
  article-title: Identity of the elusive IgM Fc receptor (FcμR) in humans
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20091107
– volume: 286
  start-page: 2156
  year: 1999
  ident: 10.1016/j.molimm.2013.10.002_bib0090
  article-title: Control of early viral and bacterial distribution and disease by natural antibodies
  publication-title: Science
  doi: 10.1126/science.286.5447.2156
– volume: 22
  start-page: 149
  year: 2010
  ident: 10.1016/j.molimm.2013.10.002_bib0130
  article-title: Identification of TOSO/FAIM3 as an Fc receptor for IgM
  publication-title: Int. Immunol.
  doi: 10.1093/intimm/dxp121
– volume: 188
  start-page: 2381
  year: 1998
  ident: 10.1016/j.molimm.2013.10.002_bib0010
  article-title: A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.188.12.2381
– volume: 19
  start-page: 837
  year: 2003
  ident: 10.1016/j.molimm.2013.10.002_bib0150
  article-title: Activation of autoreactive B cells by CpG dsDNA
  publication-title: Immunity
  doi: 10.1016/S1074-7613(03)00323-6
– volume: 15
  start-page: 203
  year: 1997
  ident: 10.1016/j.molimm.2013.10.002_bib0045
  article-title: Fc receptor biology
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.15.1.203
– volume: 416
  start-page: 603
  year: 2002
  ident: 10.1016/j.molimm.2013.10.002_bib0085
  article-title: Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
  publication-title: Nature
  doi: 10.1038/416603a
– volume: 50
  start-page: 172
  year: 2012
  ident: 10.1016/j.molimm.2013.10.002_bib0145
  article-title: Isolation and characterization of naive follicular dendritic cells
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2011.11.010
– volume: 204
  start-page: 1959
  year: 2007
  ident: 10.1016/j.molimm.2013.10.002_bib0055
  article-title: BAFF and MyD88 signals promote a lupuslike disease independent of T cells
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20062567
– volume: 16
  start-page: 421
  year: 1998
  ident: 10.1016/j.molimm.2013.10.002_bib0115
  article-title: Divergent roles for Fc receptors and complement in vivo
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.16.1.421
– volume: 17
  start-page: 230
  year: 2005
  ident: 10.1016/j.molimm.2013.10.002_bib0105
  article-title: Signaling in B cells via Toll-like receptors
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2005.03.003
– volume: 191
  start-page: 1253
  year: 2000
  ident: 10.1016/j.molimm.2013.10.002_bib0050
  article-title: Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.191.7.1253
– volume: 114
  start-page: 2
  year: 2005
  ident: 10.1016/j.molimm.2013.10.002_bib0100
  article-title: How do follicular dendritic cells interact intimately with B cells in the germinal centre?
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2004.02075.x
– volume: 207
  start-page: 2271
  year: 2010
  ident: 10.1016/j.molimm.2013.10.002_bib0075
  article-title: Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20092401
SSID ssj0006065
Score 2.0833075
Snippet •Fcα/μR enhances, rather than suppresses, autoantibody production.•Fcα/μR on the MRL/MpJ-Faslpr/lpr background mice decreased survival rate.•IgM prevents...
Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents...
SourceID proquest
pubmed
crossref
nii
elsevier
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 216
SubjectTerms Animals
antibody formation
autoantibodies
Autoantibodies - biosynthesis
Autoantibodies - blood
Autoantibodies - immunology
Autoantibody
cardiolipins
Cardiolipins - immunology
dendritic cells
Dendritic Cells, Follicular - metabolism
DNA
DNA - immunology
Fc receptor
histones
Histones - immunology
IgM
immunoglobulin A
Immunoglobulin A - immunology
immunoglobulin G
immunoglobulin M
Immunoglobulin M - immunology
Mice
Mice, Inbred BALB C
Mice, Knockout
receptors
Receptors, Fc - immunology
survival rate
Title Involvement of Fcα/μR (CD351) in autoantibody production
URI https://dx.doi.org/10.1016/j.molimm.2013.10.002
https://cir.nii.ac.jp/crid/1572543027502621824
https://www.ncbi.nlm.nih.gov/pubmed/24172225
https://www.proquest.com/docview/1462371945
https://www.proquest.com/docview/2000269140
Volume 57
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtRADLa6W0G5VLBAWUqrIHGAw3Qzv5nhVi2stqD2AFTqLZokM1JQm6wge-iFd-LOM_SZGOdnJQ6rSlxyGI0jxx557Nj-DPDGMZ5pliviZRITIY0mVghPtKKWS-G9LLDB-fxCLS_Fpyt5tQPzoRcGyyp729_Z9NZa9yuzXpqzVVnOvrbOijaYeotliBxGsMu4UXIMu6dnn5cXG4McfPSuklFRggRDB11b5nVTX5c32JJO-Ulb5sW23VCjqiy3-6HtfbR4DPu9Ixmddrw-gR1XTeBBN1rydgJ782GS2wQenvcJ9Kfw_qwK9qjFCG-i2keL_O737O7Pl-jt_AOX9F1UVpFdN3WQd5nVxW206hBhg_aeweXi47f5kvTjE0guddwQ6WOrWOGLcKPHXuROF9RKJp1lOfNGY07TMkZzhBzL4qIwlvskxBcxN5mgnj-HcVVX7gVEjjIWiEWLl2eN0sp4zpxGQDIX3j8FPogszXtscRxxcZ0ORWTf007QKQoaV4Ogp0A2VKsOW-Oe_cmgjfSfM5IG838P5VFQXmANn1QmiACA-drAPyLYiym8HtSaBt1gzsRWrl7_xMiI8YQaIbfvwW4npkwIVadw0J2JzfcEBynBkPrlf_N-CI-6DBb-9nkF4-bH2h0FR6jJjmF08ose98f9L-qSARI
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwEB61RVAuFSy0LFAIEgc4pBv_JXZvaGG1hW4P0Eq9RU5iS6naZAXZQy-8E3eeoc_ETH6KOKwqccnBsSNnxhrPaL75BuCt4yLTPI9Dr5IolMro0ErpQx0zK5T0XhVU4Lw4iedn8vO5Ot-A6VALQ7DK3vZ3Nr211v3IpJfmZFmWk2-ts6INpd4ihZHDJtyTSiSE6zv4-RfngR56h2OMWUjTh_q5FuR1VV-WV1SQzsRBC_Li6-6nzaos13uh7W00ewQ7vRsZfOh2-hg2XDWC-11jyesRbE-HPm4jeLDo0-dP4PCoQmvUMoQ3Qe2DWX7za3Lz-2vwbvpRKPY-KKvArpoapV1mdXEdLDs-WNTdUzibfTqdzsO-eUKYKx01ofKRjXnhC7zPIy9zpwtmFVfO8px7oymjaTlnORGOZVFRGCt8gtFFJEwmmRe7sFXVlXsGgWOc42LZsuVZE-vYeMGdJjoyh98fgxhEluY9szg1uLhMBwjZRdoJOiVB0ygKegzh7aplx6xxx_xk0Eb6zwlJ0fjfsXIflYdboydTCdX_U7YW90_89XIMbwa1pqgbypjYytWrHxQXcZEwI9X6OVTrxGODgeoY9rozcfs_6B4lFFA__--9v4bt-eniOD0-OvnyAh7iG9lhxl_CVvN95fbRJWqyV-2R_wMNqQHa
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Involvement+of+Fc%CE%B1%2F%CE%BCR+%28CD351%29+in+autoantibody+production&rft.jtitle=Molecular+immunology&rft.au=Yoshizawa%2C+Yuichi&rft.au=Honda%2C+Shin-ichiro&rft.au=Shibuya%2C+Akira&rft.date=2014-02-01&rft.eissn=1872-9142&rft.volume=57&rft.issue=2&rft.spage=216&rft_id=info:doi/10.1016%2Fj.molimm.2013.10.002&rft_id=info%3Apmid%2F24172225&rft.externalDocID=24172225
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0161-5890&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0161-5890&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0161-5890&client=summon