Task activations produce spurious but systematic inflation of task functional connectivity estimates

• Published in: NeuroImage (Orlando, Fla.) Vol. 189; pp. 1 - 18
• Main Authors: Cole, Michael W., Ito, Takuya, Schultz, Douglas, Mill, Ravi, Chen, Richard, Cocuzza, Carrisa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2019; Elsevier Limited
• Subjects: Animal cognition; Brain - diagnostic imaging; Brain - physiology; Brain mapping; Computational modeling; Computational neuroscience; Connectome - standards; fMRI; Functional connectivity; Functional magnetic resonance imaging; Functional Neuroimaging - standards; Humans; Hypotheses; Magnetic Resonance Imaging - standards; Mental Processes - physiology; Method validation; Models, Theoretical; Networks; Neural networks; Neural Networks, Computer; Researchers; Studies; Time series; Functional connectivity; Networks; fMRI; Computational modeling; Method validation

Most neuroscientific studies have focused on task-evoked activations (activity amplitudes at specific brain locations), providing limited insight into the functional relationships between separate brain locations. Task-state functional connectivity (FC) – statistical association between brain activi...