A Recombinant Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Complex Stabilized by an Intermolecular Disulfide Bond between the gp120 and gp41 Subunits Is an Antigenic Mimic of the Trimeric Virion-Associated Structure

• Published in: Journal of Virology Vol. 74; no. 2; pp. 627 - 643
• Main Authors: Binley, J M, Sanders, R W, Clas, B, Schuelke, N, Master, A, Guo, Y, Kajumo, F, Anselma, D J, Maddon, P J, Olson, W C, Moore, J P
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.01.2000
• Subjects: AIDS/HIV; Amino Acid Sequence; Amino Acid Substitution; Antigens, Viral - genetics; Antigens, Viral - immunology; Antigens, Viral - metabolism; Cell Line, Transformed; Centrifugation, Density Gradient; Chromatography, Gel; Cysteine - genetics; Disulfides - metabolism; env Gene Products, Human Immunodeficiency Virus; envelope protein; Furin; Gene Products, env - genetics; Gene Products, env - immunology; Gene Products, env - metabolism; glycoprotein gp120; glycoprotein gp140; glycoprotein gp41; Glycoproteins - genetics; Glycoproteins - immunology; Glycoproteins - metabolism; HIV Envelope Protein gp120 - genetics; HIV Envelope Protein gp120 - immunology; HIV Envelope Protein gp120 - metabolism; HIV Envelope Protein gp41 - genetics; HIV Envelope Protein gp41 - immunology; HIV Envelope Protein gp41 - metabolism; HIV-1 - isolation & purification; Human immunodeficiency virus 1; Humans; Molecular Sequence Data; Protein Processing, Post-Translational; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - immunology; Recombinant Fusion Proteins - metabolism; Subtilisins - metabolism; Sucrose; Vaccines and Antiviral Agents; Virion
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.74.2.627-643.2000

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