Development of an Immunochromatography Assay to Detect Marburg Virus and Ravn Virus

The recent outbreaks of Marburg virus disease (MVD) in Guinea, Ghana, Equatorial Guinea, and Tanzania, none of which had reported previous outbreaks, imply increasing risks of spillover of the causative viruses, Marburg virus (MARV) and Ravn virus (RAVV), from their natural host animals. These outbr...

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Published inViruses Vol. 15; no. 12; p. 2349
Main Authors Changula, Katendi, Kajihara, Masahiro, Muramatsu, Shino, Hiraoka, Koji, Yamaguchi, Toru, Yago, Yoko, Kato, Daisuke, Miyamoto, Hiroko, Mori-Kajihara, Akina, Shigeno, Asako, Yoshida, Reiko, Henderson, Corey W., Marzi, Andrea, Takada, Ayato
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 29.11.2023
Subjects
Animals
Antibodies, Monoclonal
Antigens
blood serum
Chromatography, Affinity
Diagnosis
Ebola virus
Epidemics
Equatorial Guinea
Fever
filovirus
Ghana
Guinea
Health aspects
Identification and classification
immunoaffinity chromatography
Immunoassay
Infections
Infectious diseases
Laboratory animals
Marburg disease
Marburg marburgvirus
Marburg virus
Marburg Virus Disease
Marburgvirus
MARV
Methods
Monoclonal antibodies
monoclonal antibody
nucleoprotein
Nucleoproteins
Outbreaks
Plasmids
point-of-care testing
Ravn virus
RNA polymerase
RNA viruses
Tanzania
Tissue culture
Viruses
Japan
Angola
Ghana
Guinea
Equatorial Guinea
Tanzania
RDT
Ravn virus
Marburg virus
immunochromatography assay
nucleoprotein
diagnosis
rapid diagnostic test
MARV
monoclonal antibody
filovirus
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Abstract The recent outbreaks of Marburg virus disease (MVD) in Guinea, Ghana, Equatorial Guinea, and Tanzania, none of which had reported previous outbreaks, imply increasing risks of spillover of the causative viruses, Marburg virus (MARV) and Ravn virus (RAVV), from their natural host animals. These outbreaks have emphasized the need for the development of rapid diagnostic tests for this disease. Using monoclonal antibodies specific to the viral nucleoprotein, we developed an immunochromatography (IC) assay for the rapid diagnosis of MVD. The IC assay was found to be capable of detecting approximately 102−4 50% tissue culture infectious dose (TCID50)/test of MARV and RAVV in the infected culture supernatants. We further confirmed that the IC assay could detect the MARV and RAVV antigens in the serum samples from experimentally infected nonhuman primates. These results indicate that the IC assay to detect MARV can be a useful tool for the rapid point-of-care diagnosis of MVD.
AbstractList The recent outbreaks of Marburg virus disease (MVD) in Guinea, Ghana, Equatorial Guinea, and Tanzania, none of which had reported previous outbreaks, imply increasing risks of spillover of the causative viruses, Marburg virus (MARV) and Ravn virus (RAVV), from their natural host animals. These outbreaks have emphasized the need for the development of rapid diagnostic tests for this disease. Using monoclonal antibodies specific to the viral nucleoprotein, we developed an immunochromatography (IC) assay for the rapid diagnosis of MVD. The IC assay was found to be capable of detecting approximately 102−4 50% tissue culture infectious dose (TCID50)/test of MARV and RAVV in the infected culture supernatants. We further confirmed that the IC assay could detect the MARV and RAVV antigens in the serum samples from experimentally infected nonhuman primates. These results indicate that the IC assay to detect MARV can be a useful tool for the rapid point-of-care diagnosis of MVD.
The recent outbreaks of Marburg virus disease (MVD) in Guinea, Ghana, Equatorial Guinea, and Tanzania, none of which had reported previous outbreaks, imply increasing risks of spillover of the causative viruses, Marburg virus (MARV) and Ravn virus (RAVV), from their natural host animals. These outbreaks have emphasized the need for the development of rapid diagnostic tests for this disease. Using monoclonal antibodies specific to the viral nucleoprotein, we developed an immunochromatography (IC) assay for the rapid diagnosis of MVD. The IC assay was found to be capable of detecting approximately 10[sup.2−4] 50% tissue culture infectious dose (TCID[sub.50] )/test of MARV and RAVV in the infected culture supernatants. We further confirmed that the IC assay could detect the MARV and RAVV antigens in the serum samples from experimentally infected nonhuman primates. These results indicate that the IC assay to detect MARV can be a useful tool for the rapid point-of-care diagnosis of MVD.
The recent outbreaks of Marburg virus disease (MVD) in Guinea, Ghana, Equatorial Guinea, and Tanzania, none of which had reported previous outbreaks, imply increasing risks of spillover of the causative viruses, Marburg virus (MARV) and Ravn virus (RAVV), from their natural host animals. These outbreaks have emphasized the need for the development of rapid diagnostic tests for this disease. Using monoclonal antibodies specific to the viral nucleoprotein, we developed an immunochromatography (IC) assay for the rapid diagnosis of MVD. The IC assay was found to be capable of detecting approximately 10 50% tissue culture infectious dose (TCID )/test of MARV and RAVV in the infected culture supernatants. We further confirmed that the IC assay could detect the MARV and RAVV antigens in the serum samples from experimentally infected nonhuman primates. These results indicate that the IC assay to detect MARV can be a useful tool for the rapid point-of-care diagnosis of MVD.
The recent outbreaks of Marburg virus disease (MVD) in Guinea, Ghana, Equatorial Guinea, and Tanzania, none of which had reported previous outbreaks, imply increasing risks of spillover of the causative viruses, Marburg virus (MARV) and Ravn virus (RAVV), from their natural host animals. These outbreaks have emphasized the need for the development of rapid diagnostic tests for this disease. Using monoclonal antibodies specific to the viral nucleoprotein, we developed an immunochromatography (IC) assay for the rapid diagnosis of MVD. The IC assay was found to be capable of detecting approximately 102-4 50% tissue culture infectious dose (TCID50)/test of MARV and RAVV in the infected culture supernatants. We further confirmed that the IC assay could detect the MARV and RAVV antigens in the serum samples from experimentally infected nonhuman primates. These results indicate that the IC assay to detect MARV can be a useful tool for the rapid point-of-care diagnosis of MVD.The recent outbreaks of Marburg virus disease (MVD) in Guinea, Ghana, Equatorial Guinea, and Tanzania, none of which had reported previous outbreaks, imply increasing risks of spillover of the causative viruses, Marburg virus (MARV) and Ravn virus (RAVV), from their natural host animals. These outbreaks have emphasized the need for the development of rapid diagnostic tests for this disease. Using monoclonal antibodies specific to the viral nucleoprotein, we developed an immunochromatography (IC) assay for the rapid diagnosis of MVD. The IC assay was found to be capable of detecting approximately 102-4 50% tissue culture infectious dose (TCID50)/test of MARV and RAVV in the infected culture supernatants. We further confirmed that the IC assay could detect the MARV and RAVV antigens in the serum samples from experimentally infected nonhuman primates. These results indicate that the IC assay to detect MARV can be a useful tool for the rapid point-of-care diagnosis of MVD.
The recent outbreaks of Marburg virus disease (MVD) in Guinea, Ghana, Equatorial Guinea, and Tanzania, none of which had reported previous outbreaks, imply increasing risks of spillover of the causative viruses, Marburg virus (MARV) and Ravn virus (RAVV), from their natural host animals. These outbreaks have emphasized the need for the development of rapid diagnostic tests for this disease. Using monoclonal antibodies specific to the viral nucleoprotein, we developed an immunochromatography (IC) assay for the rapid diagnosis of MVD. The IC assay was found to be capable of detecting approximately 10²⁻⁴ 50% tissue culture infectious dose (TCID₅₀)/test of MARV and RAVV in the infected culture supernatants. We further confirmed that the IC assay could detect the MARV and RAVV antigens in the serum samples from experimentally infected nonhuman primates. These results indicate that the IC assay to detect MARV can be a useful tool for the rapid point-of-care diagnosis of MVD.
Audience Academic
Author Yoshida, Reiko
Hiraoka, Koji
Muramatsu, Shino
Henderson, Corey W.
Takada, Ayato
Changula, Katendi
Yamaguchi, Toru
Mori-Kajihara, Akina
Shigeno, Asako
Miyamoto, Hiroko
Kajihara, Masahiro
Yago, Yoko
Kato, Daisuke
Marzi, Andrea
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/38140590$$D View this record in MEDLINE/PubMed
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Keywords RDT
Ravn virus
Marburg virus
immunochromatography assay
nucleoprotein
diagnosis
rapid diagnostic test
MARV
monoclonal antibody
filovirus
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Snippet The recent outbreaks of Marburg virus disease (MVD) in Guinea, Ghana, Equatorial Guinea, and Tanzania, none of which had reported previous outbreaks, imply...
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SubjectTerms Animals
Antibodies, Monoclonal
Antigens
blood serum
Chromatography, Affinity
Diagnosis
Ebola virus
Epidemics
Equatorial Guinea
Fever
filovirus
Ghana
Guinea
Health aspects
Identification and classification
immunoaffinity chromatography
Immunoassay
Infections
Infectious diseases
Laboratory animals
Marburg disease
Marburg marburgvirus
Marburg virus
Marburg Virus Disease
Marburgvirus
MARV
Methods
Monoclonal antibodies
monoclonal antibody
nucleoprotein
Nucleoproteins
Outbreaks
Plasmids
point-of-care testing
Ravn virus
RNA polymerase
RNA viruses
Tanzania
Tissue culture
Viruses
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Title Development of an Immunochromatography Assay to Detect Marburg Virus and Ravn Virus
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Volume 15
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